Pengembangan Sediaan Krim Pencerah Kulit dari Kombinasi Ekstrak Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) dan Ekstrak Biji Kacang Kedelai (Gl ycine Max (L.) Merill)

  • Leni Nurlina Yanti UNIVERSITAS PANCASILA
  • Anny Victor Purba
  • Ratna Djamil

Abstract

Javanese turmeric (Curcuma xanthorrhiza) and soybean (Glycine max L. Merill) are natural ingredients
that can be used to treat face skin. The aim of this study was to formulate extracts of Javanese turmeric and
soybean in the form of skin lightening cream preparations.. In this experiment, four cream formulations
were made containing a combination of javanese tumeric extract with concentrations of 1%, 3%, 5% and
10% and soybean extract with concentrations of 5% and 15%. Accelerated cream formulations stability
test for 1 month was tested by observing the results of its storage at low temperatures, room temperature
and high temperature which included organoleptic observation, pH and homogeneity where each formula
showed physical stability for 4 weeks, pH average 4.5-5.0, and no change in cream color. The irritation
test was tested by using the acute dermal irritation method using rabbits and was declared safe and not
irritating. The effectiveness test was measured by applying a combination cream to the respondents and
measuring the brightness of the skin using a Dermalab examination measured after using the cream.
The combination cream with a variation of 10% javanese tumeric concentration and 15% soybean
concentration was the highest L* score in lightening the skin.

Key words: Curcuma rhizome extract; soybean seed extract; cream;skin lingkening

 

 

 

 

References

Rohmah SD. Formulasi krim sarang burung walet putih (Aerodramus fuciphagus) dengan basis tipe A/M sebagai pencerah kulit wajah. Pontianak: Jurnal Mahasiswa Farmasi Fakultas Kedokteran Universitas Tanjungpura; 2013, h 3-4.

Hollinger AC, Angra K, Halder RM. Are natural ingredients effective in the management of hyperpigmentation? A systematic review. J Clin Aesthet Dermatol. 2018; 11(2):28–37.

Singhal A, Kumar D, Bansal M,. Skin whitening – a brief review, Pharmatutor-Art-1853, 2015; www.pharmatutor.org, Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology.

Supriadi. Tumbuhan Obat Indonesia: Penggunaan dan Khasiatnya. Jakarta: Pustaka Populer Obor; 2001, h 130-133.

Kartasapoetra G. Budidaya Tanaman Berkhasiat Obat. Jakarta: PT. Rineka Cipta; 2006.

Afifah E, Tim Lentera. Khasiat dan Manfaat Temulawak. Rimpang. Penyembuh Aneka Penyakit. Jakarta: Agro Media Pustaka; 2005.

Mahendra B. 13 Jenis Tanaman Obat Ampuh. Jakarta: Penebar Swadaya; 2005.

Choi MA, Kim SH, Chung WY, Hwang JK, Park KK. Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model: Biochemical and Biophysical Research Communications; 2005, 326: 210-217.

Nurcholis W, Ambarsari L, Sari EK, Darusman LK. Curcuminoid contents, antioxidant and anti-inflammatory activites of Curcuma xanthorrhiza Roxb. and Curcuma domestica val. Promising lines from Sukabumi, Indonesia. prosiding seminar nasional kimia. Surabaya: Universitas Negeri Surabaya; 2012.

Hwang JK, Shin JS, Pyun YR. Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogen. Fitoterapia; 2000, volume 71: h 321.

Batubara I, Julita I, Darusman LK., Muddhatir AM, Mitsunaga T. Flower bracts of temulawak (Curcuma xanthorrhiza) for skin care: antiacne and whitening agents. Procedia Chem; 2015; 14:18.

Cahyadi W. Kedelai: Teknologi dan Khasiat Kedelai. Jakarta: Bumi Aksara; 2007.

Susila D, Susanto. Kedelai, Deskripsi, Budidaya dan Sertifikasi Benih. Surabaya: Expert JICA-SSP; 2003.

Departemen Kesehatan Republik Indonesia. Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta : Direktorat Jenderal Pengawasan Obat dan Makanan; 2002.

Herdiana S, Muztabadihardja. Formulasi krim pencerah wajah ekstrak etanol 70% daun ciplukan (Physalis angulata L.). Bogor: Jurnal Penelitian Program Studi Farmasi FMIPA, Universitas Pakuan Bogor; 2014, h 7.

Juwita AP, Yamlean PV dan Edy HJ. Formulasi krim ekstrak etanol daun lamun (Syringodium isotifolium). Manado: Jurnal Ilmiah Farmasi Universitas Sram Ratulangi, 2013; 1(2): 27.

Lu FC.Basic Toxicology: fundamental, target organs and risk assessment, 4th ed. London: New Fetter Lane; 2002.

Fitzpatrick RE, Goldman MP. Laser and energy devices for the skin, 2nd ed. New Yor: CRC Press; 2013.

Kawada A, Shiraishi H and Aragane Y. A new approach to the evaluation of whitening effect of a cosmetic using computer analysis of video captured image. ; 2002, hal 97.

Peraturan Ka BPOM Nomor 12 Tahun 2014 tentang persyaratan mutu obat tradisional.

Younis. Stability Testing in Pharmacy: review. International Journal of Institutional Pharmacy and Life Sciences, 2015, 5(1): 108.

ICH: Harmonised tripartite guideline. Stability Testing of New Drug Substances and Products Q1A (R2); 2003, h 3.

Standar Nasional Indonesia. Sediaan Tabir Surya SNI 16- 4399-1996. Jakarta: Badan Standarisasi Nasional; 2000.

Hayes AW. Principles and Methods of Toxicology. Raven press. New York. 2002.

Departemen Kesehatan Republik Indonesia. Farmakope Indonesia. Edisi IV. Jakarta : Direktorat Jenderal Pengawasan Obat dan Makanan; 1995.

Padmawinada K, Soediro I. Penuntun Cara Modern Menganalisa Tumbuhan. Bandung: Institute Teknologi Bandung; 1987(2): 104-354 Dikutip dari – J.B.Harborne, phytochemical methods. ISBN 979-800-14-1. H 104,352.

Branen PM, Davidson LA. Antimicrobial in Foods. 2nd ed. New York: Marcel Dekker; 2001.

Tranggono, Iswari R, Latifah. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: Gramedia Pustaka Utama; 2007.

Djuanda S. Dermatitis, Dalam: Ilmu Penyakit Kulit dan Kelamin, Ed. 3. Jakarta: FK UI; 2002.

Iswari R, Latifa F. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: Gramedia Pustaka Utama; 2007.

Saputra JS. Formula Dasar Kosmetika, Garandi Academic Press. Jakarta: Garandi Academic Press; 2003.

Singh S. Stability Testing During Product Development in Jain Nk Pharmaceutical Product Development. India: CBS Publisher and Distributors; 2000, h 272-293.

Tangri A. Who role and guidelines in stability study of pharmaceuticals: regulatory perspective: International Journal of Research in Pharmaceutical and Biomedical Science; 2012: 3(3): 29.

David A. Fast track: Physical Pharmacy, 1st edition. London: Pharmaceutical Press; 2008.

Kim HW. Characterization and quantification of gamma-oryzanol in grains of 16 Koreans rice varieties. International Journal of Food Sciences and Nutrition, 2012, volume 66(2): 166.

Naveed B, Qamar. Stability of a dosage form and forced degradation studies: Journal of Bioequivalence and Bioavailability, 2016, volume 8(4): 191.

Panda. Stability studies: integral part of drug development process: International journal of Pharmaceutical Research and Bioscience, 2013, Volume 2(6): 69-80.

Carstensen. Drug Stability Principles and Practice. New York: Marcel Dekker Inc; 2000.

Peraturan Ka BPOM Nomor 7 Tahun 2014 Tentang Uji Toksisitas non Klinik secara in vivo. Jakarta: BPOM; 2014.

Published
2019-06-19
How to Cite
1.
Yanti L, Purba A, Djamil R. Pengembangan Sediaan Krim Pencerah Kulit dari Kombinasi Ekstrak Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) dan Ekstrak Biji Kacang Kedelai (Gl ycine Max (L.) Merill). bpk [Internet]. 19Jun.2019 [cited 5May2024];47(1):55-6. Available from: http://ejournal2.litbang.kemkes.go.id/index.php/bpk/article/view/1385
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