Hubungan antara Faktor Reproduksi dengan Tumor Payudara Berdasarkan Pemeriksaan Sadanis, Riset Penyakit Tidak Menular 2016

  • Lusianawaty Tana 081224734959
Keywords: Tumor payudara, reproduksi, faktor risiko, pemeriksaan payudara klinis



Breast cancer is the most frequently diagnosed cancer in females worldwide. It was 18% of all cancer in 2012 and was in the fourth rank of mortality caused by cancer. Factors which is still speculated as risk factors of breast cancer are reproductive factors: never pregnant, only one pregnancy, and no breastfeeding. This secondary analysis of Non Communicable Diseases Research 2016 data aims to assess the relationship between reproductive factors with breast tumor among 43,948 Indonesian women of aged 25-64 years using logistic regression analysis with 5% significance and 95% confidence interval. The results showed breast tumor was higher in women aged 35 years and over compared with under 35 years, menarche at age 7-12 years compared with 13-25 years, first childbirth at 31-35 years and 36-47 years compared with under 30 years, having less than 3 children compared with ≥ 3 children and no child or only 1 child breastfed compared with ≥ 2 children breastfed. The analysis concluded that breast tumor was related to number of child breastfed, frequency of childbirth, and late first childbirth.

Keywords: breast tumor, reproductive, risk factor, clinical breast examination


Kanker payudara merupakan kanker yang tersering pada perempuan di dunia yaitu 18% dari semua kasus kanker tahun 2012 dan sebagai penyebab kematian ke empat dari kematian karena kanker untuk semua jenis. Faktor risiko kanker payudara yang masih spekulasi antara lain faktor reproduksi, seperti tidak pernah hamil, hamil hanya sekali dan tidak menyusui. Analisis lanjut ini menganalisis faktor reproduksi terhadap tumor payudara pada perempuan di Indonesia dari Riset Penyakit Tidak Menular tahun 2016 dengan sampel 43.948 perempuan berusia 25-64 tahun. Data dianalisis dengan logistik regresi, tingkat kemaknaan 0,05 dan confidence interval 95%. Hasil analisis menunjukkan tumor payudara meningkat 1,3 kali pada kelompok umur 35 tahun ke atas dibandingkan umur kurang dari 35 tahun, haid pertama pada umur 7-12 tahun dibandingkan dengan umur 13-25 tahun, umur melahirkan anak pertama 31-35 tahun dan 36-47 tahun dibandingkan umur kurang 30 tahun, jumlah anak kurang dari 3 orang dibandingkan 3 orang atau lebih dan tidak pernah menyusui anak/menyusui anak 1 orang dan menyusui 2 orang dibandingkan menyusui lebih dari 2 orang anak. Analisis menyimpulkan bahwa peningkatan tumor payudara berhubungan dengan banyaknya anak yang disusui, anak yang dilahirkan, dan peningkatan umur saat melahirkan anak pertama.

Kata kunci: Tumor payudara, reproduksi, faktor risiko, pemeriksaan payudara klinis


Youlden DR, Cramb SM, Cheng HY, Baade PD. Incidence and mortality of female breast cancer in the Asia-Pacific region. Cancer Biol Med 2014. 11 (2) 101-115. Doi: 107497/ J.issn. 2095-3941. 2014. 02.005. [Cited at 7 March 2016]. Available from:

Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F., Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. GLOBOCAN 2012 v1.1. Lyon, France: International Agency for Research on Cancer; 2014. [Cited at 16 January 2015]. Available from:

Meister K, Morgan J. Risk factors for breast cancer. A Report by the American Council on Science and Health (ACSH).2000. [Cited at March 2016]. Available from: .

National Cancer Institute. Breast Cancer Risk in American Women - National Cancer Institute. (2012). [Cited at 24th October 2016]. Available from:

National Cancer Institute. Cancer-Causing Substances in the Environment - National Cancer Institute. (2015). [Cited at 24th October 2016]. Available at:

Purwanto, H., Handoyo, D., Haryono,S. and Harahap, W. Panduan Penatalaksanaan Kanker Payudara. Jakarta. PERABOI. 2015;15-21:40- 45.

Badan Penelitian dan Pengembangan Kesehatan. Laporan Riset Penyakit Tidak Menular Tahun 2016. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2017.

Badan Penelitian dan Pengembangan Kesehatan. Pedoman pengisian kuesioner Riset Penyakit Tidak Menular 2016. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2016.

Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11– 30. [PubMed] [GoogleScholar] [Cited at 7 March 2016]. Available from:

Abdulkareem IH. Sabiston DC, Lyerly HK. 15th ed. Philadelphia: WB Saunders Company; 1997. Sabiston textbook of surgery: The biological basis of modern surgical practice. In Abdulkareem IH. Aetio-pathogenesis of breast cancer. Niger Med J. 2013 Nov- Des;54(6):371-375. [Cited at March 2019]. Available from:

Malara NM, Leotta A, Sidoti A, Lio S, D’Angelo R, Caparello B, et al. Ageing, Hormonal behaviour and cyclin D1 in ductal breast carcinomas.Breast.2006;15:81–9.

Ereman RR, Prebil LA, Mockus M, Koblick K, Orenstein F, Benz C, Clarke CA. Recentiltrends in hormone therapy utilization and breast cancer incidence rates in the high incidence population of Marin County, California. BMC Public Health 2010, 10:228. [Cited 6 November 2019]. Available from:

Sun YS, Zhao Z, Yang ZNv, Xu F, Lu HJ, Zhu ZY, et al. Risk Factors and Preventions of Breast Cancer. Int J Biol Sci. 2017;13 (11): 1387-1397. Published online 2017 Nov 1. doi: 10.7150/ijbs.21635 [Cited at March 2019]. Available form:

Gurdal SO, Saracoglu GV, Oran ES, Yankol Y, Soybir GR. The effects of educational level on breast cancer awareness: a cross-sectional study in Turkey. Asian Pac J Cancer Prev, 2012;13(1): 295-300. [Cited at March 2019]. Available from:

Aguas F, Martins A, Gomes TP, de Sousa M, Silva DP. Portuguese Menopause Society and Portuguese Gynaecology Society. Prophylaxis approach to a-symptomatic postmenopausal women: Breast cancer. Maturitas. 2005;52(Suppl 1):S23–31.

Hsieh CC, Trichopoulos D, Katsouyanni K, Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer. 1990;46:796–800. [PubMed] [Google Scholar].

Ritte R, Lukanova A, Berrino F, Dossus L, Tjønneland A, Olsen A, Overvad TF, Overvad K, Clavel-Chapelon F, Fournier A, et al. Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study. Breast Cancer Res. 2012;14:R76.

Giles LC, Glonek GFV, Moore VM, Davies MJ and Mary A Luszcz. RLowerrage at menarche affects survival in older Australian women: results from the Australian Longitudinal Study of Ageing. BMC Public Health 2010, 10:341. [Cited 6 November 2019]. Available from:

Zhang Q, Liu LY, Wang F, Mu K, Zhigang Yu. The changes in female physical and childbearing characteristics in china and potential association with risk of breast cancer. Zhang et al. BMC Public Health 2012, 12:368. [Cited 6 November 2019]. Available from:

Dall GV, Britt KL. Estrogen effects on the mammary gland in early and late life and breast cancer risk. Front Oncol. 2017;7:110. [PMC free article] [PubMed] [Google Scholar].

Horn J, Asvold BO, Opdahl S. et al. Reproductive factors and the risk of breast cancer in old age: a Norwegian cohort study. Breast Cancer Res Treat. 2013;139:237–243. [PubMed] [Google Scholar].

Wu ZJQ, Yan-qiao ZM, Chunrong C: Relationship between menstrual and reproductive factors and female breast cancer in china: meta-analysis. Modern Preven Med 2010, 37:1262–1264.

Rosner B, Colditz GA, Willett WC. Reproductive risk factors in a prospective study of breast cancer: the Nurses’ Health Study. Am J Epidemiol. 1994;139:819–835. [PubMed] [Google Scholar].

Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet. 2002;360:187–195.

Ranasinghe HM, Ranasinghe N, Rodrigo C, Seneviratne RDA, Rajapakse S. Awareness of breast cancer among adolescent girls in Colombo, Sri Lanka: a school based study. BMC Public Health 2013, 13:1209. [Cited 6 November 2019]. Available from:

Liu LY, Wang F, Yu LX, Ma ZB, Zhang Q, Gao DZ, et al. Breast cancer awareness among women in Eastern China: a crosssectional study. BMC Public Health 2014, 14:1004, [Cited 8 November 2019]. Available from:

Thu HN, Eriksson B, Khanh TT, Petzold M, Bondjers G, Kim CNT, Thanh LN, Ascher H.Breastfeeding practices in urban and rural Vietnam. [Cited 8 November 2019]. Available from: BMC Public Health 2012, 12:964

How to Cite
Tana L. Hubungan antara Faktor Reproduksi dengan Tumor Payudara Berdasarkan Pemeriksaan Sadanis, Riset Penyakit Tidak Menular 2016. bpk [Internet]. 30Dec.2019 [cited 31May2020];47(4). Available from: