PENGARUH PENYAKIT PENYERTA/KOMORBID DAN KARAKTERISTIK INDIVIDU DENGAN KEJADIAN COVID-19 DI KOTA BOGOR TAHUN 2020
Abstract
ABSTRACT
The prevalence of confirmed COVID-19 cases is high and tends to increase, becoming the main cause of morbidity and mortality. This study aims to determine the relationship between comorbidities and individual characteristics on the incidence of COVID-19 cases in Bogor City in 2020. The research method is case controlith a sample of 289 consisting of 148 cases and 141 controls (1:1). Datas were collected online using a structured questionnaire, taken from the medical record of 5 hospitals in Bogor City who had been treated. Samples were obtained from March to September 2020. Data were analyzed univariate to see the descriptive picture, bivariate to obtain crude OR, andultivariate using logistic regression method to obtain adjusted OR. The results of multivariate analysis showed a relationship between confirmed cases of COVID-19 and several risk factors include marriage factor (OR = 2.69 at 95% CI 1.54-4.70 with p value = 0.00), diabetes Mellitus (OR=3.07 at 95%CI 1.27-7.41 with p=0.01) and risk age group factors (OR=3.44 at 95%CI 2.00-5.90 with a p=0.00). In conclusion the risk factors for the incidence of COVID-19 cases are married residents, people suffering diabetes mellitus, and residents at the risk age group (18-59 years) in Bogor City.
Keywords: COVID-19, comorbid, individual characteristics, Bogor city
ABSTRAK
Prevalensi kasus konfirmasi COVID-19 yang tinggi dan cenderung meningkat menjadi penyebab utama kesakitan dan kematian. Banyak hasil penelitian tentang faktor risiko terjadinya kasus COVID-19 yang hasilnya sangat bervariasi. Penelitian ini bertujuan untuk mengetahui hubungan antara komorbid/penyakit penyerta dan karakteristik individu terhadap kejadian kasus COVID-19 di Kota Bogor tahun 2020. Rancangan penelitian adalah case-control dengan sampel sebanyak 289 yang terdiri dari 148 kasus dan 141 kontrol (1:1). Data dikumpulkan secara daring menggunakan kuesioner terstruktur melalui aplikasi yang didapat dari data rekam medis 5 Rumah Sakit di Kota Bogor. Sampel diambil dari bulan Maret s.d. September 2020 yang pernah di rawat di RS. Data dianalisis secara univariat melihat gambaran deskriptif, secara bivariat mendapatkan crude OR dan multivariat dengan metode regresi logistic untuk mendapatkan adjusted OR. Hasil analisis multivariat menunjukkan hubungan antara kasus konfirmasi COVID-19 dengan beberapa faktor risiko di antaranya: faktor perkawinan (OR=2,69 pada 95%CI 1,54-4,70 dengan nilai p=0,00), faktor menderita diabetes mellitus (OR=3,07 pada 95%CI 1,27-7,41 dengan nilai p=0,01) dan faktor kelompok umur berisiko (OR=3,44 pada 95%CI 2,00-5,90 dengan nilai p=0,00). Kesimpulan bahwa faktor risiko kejadian kasus COVID-19 ialah penduduk yang sudah menikah, penduduk yang menderita sakit diabetes mellitus dan penduduk pada kelompok umur yang berisiko (18-59 tahun) di Kota Bogor.
Kata kunci: COVID-19, comorbid, karakteristik individu, kota Bogor
References
Brien O, Kathy. O. et al. (2020) ‘StatCan COVID-19 ’:, (45280001). COVID-19 death comorbidities in Kanada.
Bruminhent, J. et al. (2020) ‘Clinical characteristics and risk factors for coronavirus disease 2019 (COVID-19) among patients under investigation in Thailand’, PLoS ONE, 15(9 September), pp. 1–14. doi: 10.1371/journal.pone.0239250.
CDC (2020) Update CDC, Comorbidities the CDC classifies as established or possible risk factors severe COVID-19, https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html.
Deiana, G. et al. (2020) ‘Deaths in SARS-CoV-2 positive patients in Italy: The influence of underlying health conditions on lethality’, International Journal of Environmental Research and Public Health, 17(12), pp. 1–10. doi: 10.3390/ijerph17124450.
Dinkes Kota Bogor (2020) Situasi COVID-19, https://www.dinkes.kotabogor.go.id/index.php,.
Ejaz, H. et al. (2020) ‘COVID-19 and comorbidities: Deleterious impact on infected patients’, Journal of Infection and Public Health, 13(12), pp. 1833–1839. doi: 10.1016/j.jiph.2020.07.014.
Gentile, Sandro., Strollo, F. and Ceriello, A. (2020) ‘COVID-19 infection in Italian people with diabetes: Lessons learned for our future (an experience to be used)’, Diabetes Research and Clinical Practice, 162, p. 108137. doi: 10.1016/j.diabres.2020.108137.
Giannouchos TV, Sussman RA, Mier JM, Poulas K, F. K. (2020) ‘Characteristics and risk factors for COVID-19 diagnosis and adverse outcomes in Mexico’, European Respiratory Journal, 57(2), p. In press.
Gold, M. S. et al. (2020) ‘COVID-19 and comorbidities: a systematic review and meta-analysis’, Postgraduate Medicine, 0(0), pp. 749–755. doi: 10.1080/00325481.2020.1786964.
Guan, W. et al. (2020) Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis, European Respiratory Journal. doi: 10.1183/13993003.00547-2020.Supp1.
Ibrahim, F. et al. (2020) ‘Preliminary report of COVID-19 testing: experience of the clinical microbiology laboratory Universitas Indonesia, Jakarta, Indonesia’, New Microbes and New Infections, 37(April), p. 100733. doi: 10.1016/j.nmni.2020.100733.
JPW, Himmels. (2020) ‘COVID-19 and risk factors for hospital admission, severe disease and death – a rapid review, 3rd update’, Health (San Francisco), p. 31.
Kaeuffer, C. et al. (2020) ‘Clinical characteristics and risk factors associated with severe COVID-19: Prospective analysis of 1,045 hospitalised cases in North-Eastern France, March 2020’, Eurosurveillance, 25(48), pp. 1–10. doi: 10.2807/1560-7917.ES.2020.25.48.2000895.
Karyono, D. R. and Wicaksana, A. L. (2020) ‘Current prevalence, characteristics, and comorbidities of patients with COVID-19 in Indonesia’, Journal of Community Empowerment for Health, 3(2), p. 77. doi: 10.22146/jcoemph.57325.
Ko, J. et al. (2020) ‘Risk Factors for COVID-19-associated hospitalization: COVID-19-Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System’, Clinical Infectious Diseases. doi: 10.1101/2020.07.27.20161810.
Lemeshow, S.et.al. (1991) ‘Sample Size Determination in Health Studies: A Practical Manual.’, Journal of the American Statistical Association, p. 1149. doi: 10.2307/2290547.
Li, X. et al. (2020) ‘Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China’, International Journal of Infectious Diseases, 94, pp. 128–132. doi: 10.1016/j.ijid.2020.03.053.
Lu, Zeming. et al. (2020) ‘Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan’, Frontiers in Endocrinology, 11(July), pp. 1–7. doi: 10.3389/fendo.2020.00478.
Parohan, M. et al. (2021) ‘Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies’, Aging Male, 23(5), pp. 1416–1424. doi: 10.1080/13685538.2020.1774748.
Sanyaolu, A. et al. (2020) ‘Comorbidity and its Impact on Patients with COVID-19’, SN Comprehensive Clinical Medicine, 2(8), pp. 1069–1076. doi: 10.1007/s42399-020-00363-4.
Senewe, Felly. Ph. et.al. (2020) Hubungan antara Komorbid dan Perilaku Pencegahan terhadap kasus COVID-19 di Kota Bogor tahun 2020. Jakarta.
Sim, B. L. H. et al. (2020) ‘Clinical characteristics and risk factors for severe COVID-19 infections in Malaysia: A nationwide observational study’, The Lancet Regional Health - Western Pacific, 4. doi: 10.1016/j.lanwpc.2020.100055.
Soliman, A. et al. (2020) ‘Prevalence, clinical manifestations, and biochemical data of type 2 diabetes mellitus versus nondiabetic symptomatic patients with COVID-19: A comparative study’, Acta Biomedica, 91(3), pp. 1–9. doi: 10.23750/abm.v91i3.10214.
Stefan, N. et al. (2020) ‘Obesity and impaired metabolic health in patients with COVID-19’, Nature Reviews Endocrinology, 16(7), pp. 341–342. doi: 10.1038/s41574-020-0364-6.
Tjandra Yoga Aditama (2020) COVID-19 Dalam Tulisan Prof. Tjandra. Lembaga Penerbitan Badan Penelitian dan Pengembangan Kesehatan Kemkes RI, ISBN: 978-602-373-177-0, Jakarta, Indonesia.
Ugwueze, C. V. et al. (2020) ‘COVID-19 and Diabetes Mellitus: The Link and Clinical Implications’, Dubai Diabetes and Endocrinology Journal, 26(2), pp. 69–77. doi: 10.1159/000511354.
Wei, Jia. Te et al. (2020) ‘Epidemiology of and risk factors for COVID-19 infection among health care workers: A multi-centre comparative study’, International Journal of Environmental Research and Public Health, 17(19), pp. 1–11. doi: 10.3390/ijerph17197149.
WHO (2020) ‘Tatalaksana klinis infeksi saluran pernapasan akut berat ( SARI ) suspek penyakit COVID-19’, World Health Organization, 4(13 Maret), pp. 1–25. Available at: https://www.who.int/docs/default-source/searo/indonesia/covid19/tatalaksana-klinis-suspek-penyakit-covid-1935867f18642845f1a1b8fa0a0081efcb.pdf?sfvrsn=abae3a22_2.
WHO (2021) ‘WHO-convened Global Study of Origins of SARS-CoV-2 : China Part (14 January-10 February 2021)’, Joint WHO-China Study Team report, (February), p. 120.
Wu, Chaomin. et al. (2020) ‘Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China’, JAMA Internal Medicine, 180(7), pp. 934–943. doi: 10.1001/jamainternmed.2020.0994.
Wu, Yuqin. et al. (2020) ‘Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19’, Clinica Chimica Acta, 509, pp. 220–223. doi: 10.1016/j.cca.2020.06.026.
Xiaochen Li, M., Shuyun Xu, M. and Muqing Yu (2020) ‘Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan’, Israel Journal of Psychiatry and Related Sciences, 19(2), pp. 165–172.
Yang, Jing. et al. (2020) ‘Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis’, International Journal of Infectious Diseases, 94, pp. 91–95. doi: 10.1016/j.ijid.2020.03.017.
Zakeri, Rosita. et al. (2020) ‘A case-control and cohort study to determine the relationship between ethnic background and severe COVID-19’, EClinicalMedicine, 28, p. 100574. doi: 10.1016/j.eclinm.2020.100574.
