Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin

Febia Arien Lestari; Wahida Hajrin; Nisa Isneni Hanifa

doi:10.22435/jki.v10i2.2496

Febia Arien Lestari Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
Wahida Hajrin Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
Nisa Isneni Hanifa Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia

DOI: https://doi.org/10.22435/jki.v10i2.2496

Keywords: Katuk leave, Cream, Simplex Lattice Design, Design Expert

Abstract

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.

References

Hidayat R, Safitri RAA, Umar TP, Maretzka A. The efficacy of sauropus androgynus leaves extract to improve cognitive function in wistar rats induced alzheimer’s. Bioscientia Medicina. 2018;2(3):35–44.

Bunawan H, Bunawan SN, Baharum SN, Noor NM. Sauropus androgynus (L.) Merr. induced bronchiolitis obliterans: from botanical studies to toxicology. Evidence-Based Complementary and Alternative Medicine. 2015 Aug;2015(714158):1–7.

Majid TS, Muchtaridi. Aktivitas farmakologi ekstrak daun katuk (Sauropus androgynus (L.) Merr). Farmaka. 2018;16(2):398–405.

Nurdianti L, Tuslinah L. Uji efektivitas antioksidan krim ekstrak etanol daun katuk (Sauropus androgynus ( L ) Merr) terhadap DPPH (1,1-diphenyl-2-picrylhydrazil). Jurnal Kesehatan Bakti Tunas Husada. 2017;17(1):87–96.

Diah FN. Formulasi krim ekstrak daun katuk (Sauropus androgynus (L.) Merr.) sebagai antioksidan dengan variasi emulgator anionik dan nonionik [skripsi]. Surakarta: Universitas Setia Budi; 2017.

Lees M. Skin care: beyond the basics. 4th ed. New York: Cengage Learning; 2012.

Yuslianti ER. Pengantar radikal bebas dan antioksidan. Yogyakarta: Dee publish; 2018.

Ebrahimzadeh MA, Enayatifard R, Khalili M, Ghaffarloo M, Saeedi M, Charati JY. Correlation between Sun Protection Factor and Antioxidant Activity, Phenol, and Flavonoid Contents of some Medicinal Plants. Iranian Journal of Pharmaceutical Research. 2014;13(3):1041–7.

Baki G, Alexander KS. Introduction to cosmetic formulation and technology. New Jersey: John Wiley & Sons; 2015.

Ma JKH, Hadjiza BW. Basic physical pharmacy. Burlinton: Jones & Bartlett Learning; 2013.

Jankowski A, Dyja R, Sarecka-Hujar B. Dermal and transdermal delivery of active substances from semisolid bases. Indian Journal of Pharmaceutical Sciences. 2017;79(4):488–500.

Florentia S. Optimasi formula tablet hisap ekstrak buah mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.) menggunakan campuran pengisi laktosa-sorbitol dengan metode Simplex Lattice Design [skripsi]. Surakarta: Universitas Muhammadiyah Surakarta; 2013.

Roosdiana A, Yudandi SA, Erika A. The potency of ethanolic extract of Sauropus androgynus (L.) Merr leaves as therapeutic herbal of rats (Rattus norvegicus) peptic ulcer model induced by aspirin. International Conference on Chemistry and Material Science. 2017 Nov; Bristol, England: IOP publishing ltd; 2018. p.1-5

Hasimun P, Aligita W, Nopitasari I. Anti-anemic and analgesic activity of Sauropus androgynous L Merr on female mice model. International Journal of Pharmaceutical and Phytopharmacological Research. 2018;8(1):98–102.

Pebriana RB, Lukitaningsih E. Deklorofilasi ekstrak metanolik daun kenikir (Cosmos caudatus Kunth.), daun mengkudu (Morinda citrifolia), dan daun mangga (Mangifera indica L.) dengan teknik elektrokoagulasi. Traditional Medicine Journal. 2017;22(3):190–8.

Susanti N, Budiman I, Warditiani N. Skrining fitokimia ekstrak etanol 90% daun katuk (Sauropus androgynus (L.) Merr.). Jurnal Farmasi Udayana. 2014;3(1):83–6.

Shanmugam S, Kumar TS, Selvam KP. Laboratory handbook on biochemistry. 2nd ed. Delhi: PHI Learning Private Limited; 2019.

Arief D, Sangi M, Kamu V. Skrining fitokimia dan uji toksisitas ekstrak biji aren (Arenga pinnata MERR.). Jurnal MIPA. 2017;6(2):12–5.

Darmawijaya IP. Skrining fitokimia ekstrak etanol daun pancasona (Tinospora coriaceae Beumee.). Virgin: Jurnal Ilmiah Kesehatan dan Sains. 2015;1(1):69–75.

Azkiya Z, Ariyani H, Nugraha TS. Evaluasi sifat fisik krim ekstrak jahe merah (Zingiber officinale Rosc. var. rubrum) sebagai anti nyeri. Journal of Current Pharmaceutica Sciences. 2017;1(1):12–8.

Astuti D, Husni P, Hartono K. Formulasi dan uji stabilitas fisik sediaan gel antiseptik tangan minyak atsiri bunga lavender (Lavandula angustifolia Miller). Farmaka. 2017;15(1):176–84.

Gyawali R, Paudel N, Shrestha S, Silwal A. Formulation and evaluation of antibacterial and antioxidant polyherbal lotion. Journal of Institute of Science and Technology. 2016;21(1):148–56.

Saryanti D, Setiawan I, Safitri RA. Optimasi formula sediaan krim M/A dari ekstrak kulit pisang kepok (Musa acuminata L.). Jurnal Riset Kefarmasian Indonesia. 2019;1(3):225–37.

Ng E. Optimasi krim sarang burung walet putih (Aerodramus fuciphagus) tipe M/A dengan variasi emulgator sebagai pencerah kulit menggunakan simplex lattice design [skripsi]. Pontianak: Universitas Tanjungpura; 2013.

Bosca F, Ticona JC, Giménez A, Flores N, Chuqui R, Barge A, et al. Chlorophylls: from evanta by product to natural porphyrin source. Journal of Universities and International Development Cooperation. 2017;1:35–42.

Aniszweski T. Alkaloid: Chemistry, biology, ecology, and applications. 2nd ed. Oxford: Elsevier; 2015.

Desnita R, Luliana S, Anastasia DS, Yuswar MA. Antiinflammatory Activity patch ethanol extract of leaf katuk (Sauropus androgynus L. Merr). Jurnal Ilmu Kefarmasian Indonesia. 2018;16(1):1–5.

Dina A, Pramono S, Sugihartini N. Optimasi komposisi emulgator dalam formulasi krim fraksi etil asetat ekstrak kulit batang nangka (Artocarpus heterophyllus Lamk). Jurnal Ilmu Kefarmasian Indonesia. 2017;15(2):134–9.

Garg A, Aggarwal D, Garg S, Singla A. Spreading of semisolid formulations an update. Pharmaceutical Technology. 2002;26(9):84–105.

Putranti W, Dewi NA, Widiyastuti L. Standardization of extract and characterization of emulgel formula of lengkuas (Alpina galangan (L.) Wild) rhizome extract. Jurnal Farmasi Sains dan Komunitas. 2018;15(2):81–91.

Elcistia R, Zulkarnain AK. Optimasi formula sediaan krim o/w kombinasi oksibenzon dan titanium dioksida serta uji aktivitas tabir suryanya secara in vivo. Majalah Farmaseutik. 2018;14(2):63–78.

Safitri NA, Puspita OE, Yurina V. Optimasi formula sediaan krim ekstrak stroberi (Fragaria x ananassa) sebagai krim antipenuaan. Majalah Kesehatan Fakultas Kedokteran Universitas Braijaya. 2014;1(4):235–46.

Allen L, Ansel H. Ansel’s : Pharmaceutical dosage forms and drug delivery systems. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2014.