Formulasi dan Uji Penetrasi Sediaan Gel Transfersom yang Mengandung Kojyl 3 Amino Propil Fosfat sebagai Pencerah Kulit

Septia Andini; Mahdi Jufri; Joshita Djajadisastra

doi:10.22435/jki.v6i2.2948

Septia Andini Universitas Pakuan, Bogor, Indonesia
Mahdi Jufri Laboratorium Teknologi Farmasi, Fakultas Farmasi, Universitas Indonesia, Depok, Indonesia
Joshita Djajadisastra Laboratorium Teknologi Farmasi, Fakultas Farmasi, Universitas Indonesia, Depok, Indonesia

DOI: https://doi.org/10.22435/jki.v6i2.2948

Keywords: Transfersome, Kojyl 3 APPA, Penetration test

Abstract

Kojyl 3 APPA is a compound used for skin lightening. Kojyl 3 APPA has a good solubility in water. This causes the hydrophilic nature kojyl 3 APPA difficult to penetrate through the skin. Transfersom is a carrier system that can improve the effectiveness of drug penetration. This study aims to formulate, characterize and evaluate transfersom preparations containing kojyl 3 APPA. Further more transfersom formulated in a gel formulation. Preparation gel was tested its physical stability and in vitro penetration test against non transfersom kojyl 3 APPA. Transfersom gel formulation is physically proven stable at room temperature, low temperature and high temperature storage. In vitro penetration tests showed that kojyl 3 APPA penetration loaded in transfersom gel was 11,16% while for non transfersom gel 8,02%

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