Formulation and Evaluation of Mangosteen (Garcinia mangostana L.) Fruit Pericarp Extract Gel
Keywords:
Garcinia mangostana fruit pericarp extract, Topical, Gel, Antioxidant
Abstract
The topical antioxidant product may be useful for the treatment of oxidative stress-related skin disorder. This research aimed to evaluate a topical gel formulation of Garcinia mangostana L. fruit pericarp (GMP) extract. GMP extract was formulated into a gel and characterized for its physical properties. The antioxidant activity was evaluated based on the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The ability of gel formulation to release GMP extract and promote skin delivery was estimated based on DPPH scavenging method and also compared to that of suspension form. The results showed that the GMP extract gel showed characteristics for topical application. The radical DPPH scavenging activity was confirmed both in GMP extract and GMP extract gel. In vitro study release showed that the GMP extract was released from gel. Some degree of GMP extract was also delivered into the shed snakeskin in vitro. When compared with the suspension form, GMP extract gel provided a more profoundly lower release.References
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23. Tjahjani S, Widowati W, Khiong K, Suhendra A, Tjokropranoto R. Antioxidant properties of Garcinia mangostana L (mangosteen) rind. Procedia Chemistry. 2014;13:198-203.
24. Abdalrahim F, Khalid M, Mohammad J, Zhari I, Amin M. Quantification of ά-, β-and γ-mangostin in Garcinia mangostana fruit rind extracts by a reverse phase high performance liquid chromatography. Journal of Medicinal Plant Research. 2012;6:4526-34.
25. Tatiya-aphiradee N, Chatuphonprasert W, Jarukamjorn K. In vivo antibacterial activity of Garcinia mangostana pericarp extract against methicillin-resistant Staphylococcus aureus in a mouse superficial skin infection model. Pharmaceutical Biology. 2016;54(11):2606-15.
26. Ngawhirunpat T, Opanasopi P, Sukma M, Sittisombut C, Kat A, Adachi I. Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana). Pharmaceutical Biology. 2010;48(1):55-62.
27. Astuti KW, Wijayanti NPAD, Prasetia IGNJA, Sari DAF. Development of gel dosage form of ethyl acetate extract of mangosteen rind (Garcinia mangostana L.). Journal of Health Sciences and Medicine. 2017:28.
28. Williams AC, Barry BW. Penetration enhancers. Advanced Drug Delivery Reviews. 2012;64:128-37.
29. Özsoy Y, Güngör S, Cevher E. Vehicle effects on in vitro release of tiaprofenic acid from different topical formulations. Il Farmaco. 2004;59(7):563-6.
30. Kouchak M, Handali S. Effects of various penetration enhancers on penetration of aminophylline through shed snake skin. Jundishapur Journal Of Natural Pharmaceutical Products. 2014;9(1):24.
2. Ribeiro A, Estanqueiro M, Oliveira M, Sousa Lobo J. Main benefits and applicability of plant extracts in skin care products. Cosmetics. 2015;2(2):48-65.
3. Martorana M, Arcoraci T, Rizza L, Cristani M, Bonina FP, Saija A, et al. In vitro antioxidant and in vivo photoprotective effect of pistachio (Pistacia vera L., variety Bronte) seed and skin extracts. Fitoterapia. 2013;85:41-8.
4. Perde-Schrepler M, Chereches G, Brie I, Tatomir C, Postescu ID, Soran L, et al. Grape seed extract as photochemopreventive agent against UVB-induced skin cancer. Journal of Photochemistry and Photobiology B: Biology. 2013;118:16-21.
5. De-Souza RO, Alves GdAD, Aguillera ALS, Rogez H, Fonseca MJV. Photochemoprotective effect of a fraction of a partially purified extract of Byrsonima crassifolia leaves against UVB-induced oxidative stress in fibroblasts and hairless mice. Journal of Photochemistry and Photobiology B: Biology. 2018;178:53-60.
6. Figueiredo SA, Vilela FMP, da Silva CA, Cunha TM, dos Santos MH, Fonseca MJV. In vitro and in vivo photoprotective/photochemopreventive potential of Garcinia brasiliensis epicarp extract. Journal of Photochemistry and Photobiology B: Biology. 2014;131:65-73.
7. Suttirak W, Manurakchinakorn S. In vitro antioxidant properties of mangosteen peel extract. Journal of Food Science and Technology. 2014;51(12):3546-58.
8. Sukatta U, Takenaka M, Ono H, Okadome H, Sotome I, Nanayama K, et al. Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (Garcinia mangostana Linn.) fruit and their contribution to antioxidative activity. Bioscience, Biotechnology, Biochemistry. 2013;77(5):984-7.
9. Lane ME. Skin penetration enhancers. International Journal of Pharmaceutics. 2013;447(1-2):12-21.
10. Pratiwi L, Fudholi A, Martien R, Pramono S. Uji Stabilitas fisik dan kimia sediaan SNEDDS (Self-nanoemulsifying drug delivery system) dan nanoemulsi fraksi etil asetat kulit manggis (Garcinia mangostana L.). Traditional Medicine Journal. 2018;23(2):84-90.
11. Mulia K, Ramadhan RM, Krisanti EA, editors. Formulation and characterization of nanoemulgel mangosteen extract in virgin coconut oil for topical formulation. MATEC Web of Conferences; 2018: EDP Sciences.
12. Chin GS, Todo H, Kadhum WR, Hamid MA, Sugibayashi K. In vitro permeation and skin retention of α-mangostin proniosome. Chemical and Pharmaceutical Bulletin. 2016;64(12):1666-73.
13. Pratiwi L, Fudholi A, Martien R, Pramono S. Self-nanoemulsifying drug delivery system (SNEDDS) for topical delivery of mangosteen peels (Garcinia mangostana L.,): formulation design and in vitro studies. Journal of Young Pharmacists. 2017;9(3).
14. Wenas DM, Jufri M, Elya B. Formulation and penetration study of liposome xanthone of mangosteen pericarp methanol extract (Garcinia mangostana L.). International Journal of Scientific and Research Publications. 2015;5(12):434-9.
15. Kuswahyuning R, Yuniarti N, Lesmana I, Fadhilah N. In vitro transport evaluation of Garcinia mangostana L. pericarp extract loaded cream and gel. International Journal of Pharmaceutical Sciences and Research. 2019;10(8):3715-22.
16. Tachaprutinun A, Meinke M, Richter H, Pan-in P, Wanichwecharungruang S, Knorr F, et al. Comparison of the skin penetration of Garcinia mangostana extract in particulate and non-particulate form. European Journal of Pharmceutics and Biopharmaceutics. 2014;86(2):307-13.
17. Kuswahyuning R. The influence of propylene glycol/water and ethanol/water binary solvents on the in vitro permeation of Garcinia mangostana L. pericarp extract across shed snakeskin. Indonesian Journal of Pharmacy. 2020.
18. Campanini MZ, Custódio DL, Ivan AL, Martins SM, Paranzini MJ, Martinez RM, et al. Topical formulations containing Pimenta pseudocaryophyllus extract: In vitro antioxidant activity and in vivo efficacy against UV-B-induced oxidative stress. AAPS PharmSciTech. 2014;15(1):86-95.
19. Fonseca YM, Catini CD, Vicentini FT, Cardoso JC, Junior RLCDA, Fonseca MJV. Efficacy of marigold extract-loaded formulations against UV-induced oxidative stress. Journal of Pharmaceutical Sciences. 2011;100(6):2182-93.
20. Helal DA, El-Rhman DA, Abdel-Halim SA, El-Nabarawi MA. Formulation and evaluation of fluconazole topical gel. Intetnational Journal of Pharmacy and Pharmaceutical Sciences. 2012;4(5):176-83.
21. Kuncari ES, Iskandarsyah I, Praptiwi P. Evaluasi, uji stabilitas fisik dan sineresis sediaan gel yang mengandung minoksidil, apigenin dan perasan herba seledri (Apium graveolens L.). Buletin Penelitian Kesehatan. 2014;42(4 Des):213-22.
22. Mahdi E, Noor A, Sakeena M, Abdullah G, Abdulkarim M, Sattar M. Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. International Journal of Nanomedicine. 2011;6:2499.
23. Tjahjani S, Widowati W, Khiong K, Suhendra A, Tjokropranoto R. Antioxidant properties of Garcinia mangostana L (mangosteen) rind. Procedia Chemistry. 2014;13:198-203.
24. Abdalrahim F, Khalid M, Mohammad J, Zhari I, Amin M. Quantification of ά-, β-and γ-mangostin in Garcinia mangostana fruit rind extracts by a reverse phase high performance liquid chromatography. Journal of Medicinal Plant Research. 2012;6:4526-34.
25. Tatiya-aphiradee N, Chatuphonprasert W, Jarukamjorn K. In vivo antibacterial activity of Garcinia mangostana pericarp extract against methicillin-resistant Staphylococcus aureus in a mouse superficial skin infection model. Pharmaceutical Biology. 2016;54(11):2606-15.
26. Ngawhirunpat T, Opanasopi P, Sukma M, Sittisombut C, Kat A, Adachi I. Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana). Pharmaceutical Biology. 2010;48(1):55-62.
27. Astuti KW, Wijayanti NPAD, Prasetia IGNJA, Sari DAF. Development of gel dosage form of ethyl acetate extract of mangosteen rind (Garcinia mangostana L.). Journal of Health Sciences and Medicine. 2017:28.
28. Williams AC, Barry BW. Penetration enhancers. Advanced Drug Delivery Reviews. 2012;64:128-37.
29. Özsoy Y, Güngör S, Cevher E. Vehicle effects on in vitro release of tiaprofenic acid from different topical formulations. Il Farmaco. 2004;59(7):563-6.
30. Kouchak M, Handali S. Effects of various penetration enhancers on penetration of aminophylline through shed snake skin. Jundishapur Journal Of Natural Pharmaceutical Products. 2014;9(1):24.
Published
2021-08-27
How to Cite
1.
Kuswahyuning R, Lesmana I. Formulation and Evaluation of Mangosteen (Garcinia mangostana L.) Fruit Pericarp Extract Gel. jki [Internet]. 27Aug.2021 [cited 27Apr.2024];11(2):90-7. Available from: http://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/3701
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