COMPLIANCE WITH ANTIRETROVIRAL THERAPY AMONG MSM AT CLINIC X, JAKARTA

  • Lu'lu Nafisah Universitas Jenderal Soedirman
Keywords: adherence, antiretroviral therapy, barriers, MSM, PLWHA

Abstract

Abstrak

Latar belakang: Kepatuhan terapeutik di Indonesia masih di bawah 80 persen dan dapat mengakibatkan peningkatan insidensi infeksi usus protozoanal, perkembangan AIDS yang lebih cepat, resistensi obat, kegagalan pengobatan, dan penularan virus ke orang lain.

Tujuan: Tujuan penelitian ini adalah untuk menggambarkan kepatuhan terhadap terapi antiretroviral pada LSL yang mencari pengobatan di klinik swasta dan menyelidiki faktor pendukung dan hambatan untuk retensi ART.

Metode: Penelitian ini menggunakan metode penelitian kualitatif dan data yang dikumpulkan melalui wawancara mendalam. Subjek penelitian dipilih dengan menggunakan purposive sampling. Data dianalisis menggunakan analisis isi.

Hasil: Informan berjumlah 7 orang, 4 ODHA, dan 3 petugas kesehatan. Hasilnya menunjukkan bahwa sebagian besar ODHA patuh dalam menggunakan terapi ARV dan mengikuti saran dokter. Faktor-faktor yang mendukung kepatuhan terhadap terapi ARV meliputi tingkat pendidikan, akses informasi, motivasi internal, hubungan pasien dengan dokter, dan dukungan sosial. Hoax, faktor yang terkait dengan pekerjaan, dan stigma adalah hambatan bagi orang yang hidup dengan HIV dalam mempertahankan kepatuhan terhadap terapi ARV.

Kesimpulan: Kepatuhan optimal terhadap terapi ARV perlu dipertahankan dan ditingkatkan karena dinamis dan dipengaruhi oleh berbagai faktor. Intervensi berbasis teknologi direkomendasikan dalam memantau kepatuhan ODHA dalam terapi ARV.

Kata Kunci: kepatuhan, terapi antiretroviral, hambatan, LSL, ODHA.

Abstract

Background: Therapeutic compliance in Indonesia was still below 80 percent and may resulted in increased incidence of protozoanal intestinal infection, faster AIDS progression, drug resistance, treatment failure, and transmission of the virus to others.

Objective: The purpose of this study was to describe adherence to antiretroviral therapy among MSM who seek treatment at private clinics and investigate facilitators and barriers to ART retention.

Method: This study used qualitative research methods and data collected through in-depth interview. The study subjects were selected using a purposive sampling. Data were analyzed using content analysis.

Results: The informants were 7 people include 4 PLWHA and 3 health workers. The results showed that most ODHA were compliant in taking ARV therapy and following doctor's advice. Factors supported adherence to ARV therapy include levels of education, access to information, internal motivation, patient relationships with doctors, and social support. Hoaxes, work related factors, and stigma are barriers to people living with HIV in sustaining ARV therapy adherence.

Conclusion: Optimal adherence to ARV therapy needs to be maintained and improved because it is dynamic and influenced by various factors. Technological interventions are recommended in monitoring PLWHA compliance in ARV therapy

Keywords: adherence, antiretroviral therapy, barriers, MSM, PLWHA.

References

1. Anasari T, Trisnawati Y. Hubungan Dukungan Keluarga Dan Pengetahuan Dengan Kepatuhan Ibu Hamil Dengan HIV Dalam Mengkonsumsi ARV Di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Bidan Prada: Jurnal Publikasi Kebidanan. 2018, 9 (1): 100-113
2. Hidayati NR, Setyaningsih I, Pandanwangi S. Tingkat kepatuhan pasien HIV/AIDS terhadap penggunaan obat antitretoviral (ARV) di RSUD Gunung Jati Cirebon. Jurnal Ilmiah Farmasi. 2018, 15(2): 58-66
3. Puspasari D, Rudi Wisaksana R, Ruslami R. Gambaran Efek Samping dan Kepatuhan Terapi Antiretroviral pada Pasien HIV di Rumah Sakit Dr. Hasan Sadikin Bandung Tahun 2015. JSK. 2018, 3(4): 175-181.
4. Green, Chris W. Seri Buku Kecil HIV-AIDS: Pengobatan untuk AIDS: Ingin Mulai?. Jakarta: Yayasan Spritia; 2012.
5. Sari NH, Rusdji SR, dan Anas R. (2017). Hubungan Tingkat Kepatuhan Konsumsi Obat Anti Retro Viral (ARV) Pada Pasien HIV dengan Kejadian Infeksi Protozoa Usus di RSUP Dr.M.Djamil Padang. Jurnal Kesehatan Andalas. 2017; 6 (2).
6. Kemenkes RI. Profil Kesehatan Indonesia Tahun 2016. Kementerian Kesehatan RI, Jakarta; 2017.
7. Angsamerah Institution. Angsamerah Institution Profile. [Internet]. 2016. Available from: https://angsamerah.com/pdf/Angsamerah-Institution_Profile_2016_en.pdf
8. Kusumowardoyo, Chrysant L. Berkualitas, Non-diskriminatif, dan Terjangkau: Klinik Yayasan Angsamerah sebagai Model Kemitraan Publik dan Swasta dalam Menyediakan Layanan untuk LSL. [Internet] Jakarta: 2014. Accessed on Februari 15, 2018 from http://www.kebijakanaidsindonesia.net/id/artikel/artikel-tematik/956-berkualitas-non-diskriminatif-dan-terjangkau-klinik-yayasan-angsamerah-sebagai-model-kemitraan-publik-dan-swasta-dalam-menyediakan-layanan-untuk-lsl.
9. Chime OH, Ndibuagu EO, Orji CJ. Rates and predictors of adherence and retention for antiretroviral therapy among HIV-positive adults in Enugu, Nigeria. Malawi Medical Journal. 2019, 31 (3): 202-211.
10. Ejigu M, Desalegn Z, Mulatu B, Mosisa G. Adherence to Combined Antiretroviral Therapy and Associated Factors Among People Living with HIV Attending Nekemte Specialized Hospital, Oromia, Ethiopia: A Cross-Sectional Study. HIV/AIDS - Research and Palliative Care. 2020, 12: 97–106
11. Leyva‑Moral JM, Loayza‑Enriquez BK, Palmieri PA, Guevara‑Vasquez GM, Elias‑Bravo UE, Edwards JE, Feijoo‑Cid M, Davila‑Olano LY, Rodriguez‑Llanos JR and Leon‑Jimenez FE. Adherence to antiretroviral therapy and the associated factors among people living with HIV/AIDS in Northern Peru: a cross‑sectional study. AIDS Res Ther (2019) 16:22. https://doi.org/10.1186/s12981-019-0238-y
12. Neupane S, Dhungana GP, Ghimire HC. Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal. BMC Public Health (2019) 19:720. https://doi.org/10.1186/s12889-019-7051-3
13. Mukui IN, Ng'ang'a L, Williamson J, Wamicwe JN, Vakil S, Katana A, et al. Rates and Predictors of Non-Adherence to Antiretroviral Therapy among HIV-Positive Individuals in Kenya: Results from the Second Kenya AIDS Indicator Survey, 2012. PLoS ONE. 2016; 11(12): e0167465.
14. Wulandari Y. Hubungan Karakteristik Pasien Dengan Tingkat Kepatuhan Terapi ARV Di Rawat Jalan Upipi Rumah Sakit Dr. Soetomo. KESMAS. 2015; 9 (1): 1~ 6.
15. Sisyahid AK, Indarjo S. Health Belief Model dan Kaitannya dengan Ketidakpatuhan Terapi Antireteroviral Pada Orang Dengan HIV/AIDS. Unnes Journal of Public Health. 2017, 6 (1).
16. Novianto AE. Gambaran Faktor-Faktor Yang Mempengaruhi Kepatuhan Konsumsi ARV Pada ODHA Di BKPM Wilayah Semarang. Artikel. Program Studi Kesehatan Masyarakat. Sekolah Tinggi Ilmu Kesehatan Ngudi Waluyoungaran. 2016.
17. Heestermans et al, 2016; Heestermans T, Browne JL, Aitken SC, et al. Determinants of adherence to antiretroviral therapy among HIV-positive adults in subSaharan Africa: a systematic review. BMJ Global Health. 2016; 1: e000125.
18. Anasari THubungan Pendidikan dan Pekerjaan dengan Kepatuhan Ibu Hamil Dengan HIV dalam Mengkonsumsi ARV Di RSUDProf.Dr. Margono Soekarjo Purwokerto. Prosiding: Seminar Nasional dan Presentasi Hasil-Hasil Penelitian Pengabdian Masyarakat. 2017; 272-283. ISBN 978-602-50798-0-1.
19. Aye WL, Puckpinyo A, Peltzer K. Non-adherence to anti-retroviral therapy among HIV infected adults in Mon State of Myanmar. BMC Public Health. 2017; 17:391.
20. Koirala S, Deuba K, Nampaisan O, Marrone G, EkstroÈm AM, for the CAT-S group. Facilitators and barriers for retention in HIV care between testing and treatment in AsiaÐA study in Bangladesh, Indonesia, Lao, Nepal, Pakistan, Philippines and Vietnam. PLoS ONE. 2017; 12 (5): e0176914.
21. Edessa D, Sisay M, Asefa F. Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis [published correction appears in PLoS One. 2019 Sep 24;14(9):e0223158]. PLoS One. 2019;14(7):e0220159. Published 2019 Jul 29. doi:10.1371/journal.pone.0220159
22. Fonsah JY, Njamnshi AK, Kouanfack C, Qiu F, Njamnshi DM, Tagny CT, et al. (2017) Adherence to Antiretroviral Therapy (ART) in YaoundeÂ-Cameroon: Association with Opportunistic Infections, Depression, ART Regimen and Side Effects. PLoS ONE 12(1): e0170893. doi:10.1371/journal.pone.0170893
23. Letta S, Demissie A, Oljira L, Dessie Y. Factors associated with adherence to Antiretroviral Therapy (ART) among adult people living with HIV and attending their clinical care, Eastern Ethiopia. BMC International Health and Human Rights. 2015; 15:33.
24. Negesa L, Demeke E, Mekonnin W. Adherence to Antiretroviral Therapy and Factors affecting among People Living with HIV/AIDS and Taking Antiretroviral Therapy, Dire Dawa Town, Eastern Ethiopia. J Infec Dis Treat. 2017, 3:1. doi:10.21767/2472-1093.100032
25. Chirambo L, Valeta M, Kamanga TMB, Nyondo-Mipando AL. Factors influencing adherence to antiretroviral treatment among adults accessing care from private health facilities in Malawi. BMC Public Health. 2019, 19:1382 https://doi.org/10.1186/s12889-019-7768-z
26. Jones D, Cook R, Cecchini D, Sued O, Bofill L, Weiss S, et al. Examining adherence among challenging patients in public and private HIV care in Argentina. AIDS Behav. 2015, 19 (9): 19–29.
27. Umeokonkwo CD, Onoka CA, Agu PA, Ossai EN, Balogun MS and Ogbonnaya LU. Retention in care and adherence to HIV and AIDS treatment in Anambra State Nigeria. BMC Infectious Diseases. 2019, 19:654. https://doi.org/10.1186/s12879-019-4293-8
28. Kim J, Lee E, Park BJ, Bang JH, and Lee JY. Adherence to antiretroviral therapy and factors afecting low medication adherence among incident HIV-infected individuals during 2009–2016: A nationwide study. Scientific Reports. 2018, 8: 3133.
29. Stojisavljevic S, Djikanovic B, Matejic B. `The Devil has entered you': A qualitative study of Men Who Have Sex With Men (MSM) and the stigma and discrimination they experience from healthcare professionals and the general community in Bosnia and Herzegovina. PLoS ONE. 2017, 12(6): e0179101. https://doi.org/10.1371/journal.pone.0179101
30. Croome N, Ahluwalia M, Hughes LD, Abas M. Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa. AIDS. 2017;31(7):995-1007. doi:10.1097/QAD.0000000000001416
31. Fisher CB, Fried AL, Macapagal K, and Mustanski B. Patient-Provider Communication Barriers and Facilitators to HIV and STI Preventive Services for Adolescent MSM. AIDS Behav. 2018 October ; 22(10): 3417–3428. doi:10.1007/s10461-018-2081-x.
32. Micheni M, Kombo BK, Secor A, Simoni JM, Operario D, Elise M. van der Elst EM, Peter Mugo P, Kanungi J, Sanders EJ, and Graham SM. Health Provider Views on Improving Antiretroviral Therapy Adherence Among Men Who Have Sex with Men in Coastal Kenya. AIDS PATIENT CARE and STDs. 2017, 31 (3). DOI: 10.1089/apc.2016.0213
33. Langebeek, N., Kooij, K. W., Wit, F. W., Stolte, I. G., Sprangers, M., Reiss, P., Nieuwkerk, P. T., & AGEhIV Cohort Study Group. Impact of comorbidity and ageing on health-related quality of life in HIV-positive and HIV-negative individuals. AIDS. 2017, 31(10), 1471–1481. https://doi.org/10.1097/QAD.0000000000001511
34. Ratnawati R. Factors Affecting Adherance Of Taking Antiretroviral Drugs In Sebaya Sehati Groups Madiun. Journal of Nursing Care & Biomolecular. 2017, 2(2): 110-114
35. Longino A, Montano MA, Sanchez H, Bayer A, Sanchez J, Tossas-Milligan K, Molina Y, Duerr A. Increasing PrEP Uptake and Adherence among MSM and TW Sex Workers in Lima, Perú: What and Whom Do Different Patients Trust?. AIDS Care. 2020 February ; 32(2): 255–260. doi:10.1080/09540121.2019.1634787
36. Loeliger KB, Niccolai LM, Mtungwa LN, Moll A, Shenoi SV. Antiretroviral therapy initiation and adherence in rural South Africa: community health workers' perspectives on barriers and facilitators. AIDS Care. 2016;28(8):982-993. doi:10.1080/09540121.2016.1164292
37. Bukenya, D., Mayanja, B.N., Nakamanya, S. et al. What causes non-adherence among some individuals on long term antiretroviral therapy? Experiences of individuals with poor viral suppression in Uganda. AIDS Res Ther 16, 2 (2019). https://doi.org/10.1186/s12981-018-0214-y
38. Legesse B, Shewamene Z. Traditional Medicine use and its impact on antiretroviral Therapy Adherence Among Hiv Patients In Ethiopia. Value in health. 2015, 18; 3, A241.
39. Ilomuanya MO, Okubanjo OO, Azubuike C, Oguntibeju A, Ajiboye D, and Maduka C. Evaluation of the frequency of use of herbal drugs with concomitant administration of highly active antiretroviral therapy and its effect on medication adherence in two health care facilities in south western Nigeria. Journal of AIDS and HIV Research. 2017, 9 (1), pp. 8-16.
40. Sabin LL, DeSilva MB, Gill CJ, Zhong L, Vian T, Xie W, Cheng F, Xu K, Lan G, Haberer JE, Bangsberg DR, Li Y, Lu H, Gifford AL. Improving Adherence to Antiretroviral Therapy With Triggered Real-time Text Message Reminders: The China Adherence Through Technology Study. J Acquir Immune Defic Syndr. 2015, 69: 551–559).
41. Abdulrahman SA, Rampal L, Ibrahim F, Radhakrishnan AP, Kadir Shahar H, et al. Mobile phone reminders and peer counseling improve adherence and treatment outcomes of patients on ART in Malaysia: A randomized clinical trial. Plos ONE. 2017, 12 (5): e0177698.
42. Shah R, Watson J, Free C. A systematic review and meta-analysis in the effectiveness of mobile phone interventions used to improve adherence to antiretroviral therapy in HIV infection. BMC Public Health. 2019;19(1):915. Published 2019 Jul 9. doi:10.1186/s12889-019-6899-6
43. Guo Y, Xu Z, Qiao J, Hong YA, Zhang H, Zeng C, Cai W, Li L, Liu C. Development and feasibility testing of an mHealth (text message and WeChat) intervention to improve the medication adherence and quality of life of people living with HIV in China: pilot randomized controlled trial. JMIR Mhealth Uhealth. 2018;6(9):e10274.
44. Muessig KE, LeGrand S, Horvath KJ, Bauermeister JA, Hightow-Weidman LB. Recent mobile health interventions to support medication adherence among HIV-positive MSM. Curr Opin HIV AIDS. 2017;12(5):432–41.
45. Demena BA, Artavia-Mora L, Ouedraogo D, Thiombiano BA, Wagner N. A Systematic Review of Mobile Phone Interventions (SMS/IVR/Calls) to Improve Adherence and Retention to Antiretroviral Treatment in Low-and Middle-Income Countries. AIDS Patient Care STDS. 2020;34(2):59-71. doi:10.1089/apc.2019.0181
Published
2020-12-29
How to Cite
1.
Nafisah L. COMPLIANCE WITH ANTIRETROVIRAL THERAPY AMONG MSM AT CLINIC X, JAKARTA. kespro [Internet]. 29Dec.2020 [cited 24Apr.2024];11(2):137-49. Available from: http://ejournal2.litbang.kemkes.go.id/index.php/kespro/article/view/3728