IODINE STATUS IN SCHOOL CHILDREN AND DISTRIBUTION OF IODINE, MERCURY, LEAD IN SOIL AND WATER IN THE ENDEMIC GOITER HILL AREA, PONOROGO

  • Muhamad Arif Musoddaq Balai Litbangkes Magelang
  • Taufiq Hidayat Balai Litbangkes Magelang
  • Khimayah Khimayah Balai Litbangkes Magelang
Keywords: IDD, iodine, lead, mercury, UIE

Abstract

Background.  Iodine deficiency disorders (IDD) remained a public health problem. Ponorogo was an IDD endemic area with prominent cases of mental retardation. Despite the lack of iodine intake, exposure to environmental heavy metals can exacerbate the effects of iodine deficiency. Objective. To describe iodine status of school children and distribution of environmental iodine and heavy metals including mercury (Hg), lead (Pb), and cadmium (Cd) in the endemic IDD hill area of Ponorogo. Method. This research is a cross-sectional study conducted in two villages in IDD endemic areas in Ponorogo, namely Dayakan and Watubonang villages, in 2011. A total of 127 urine samples of primary-school-age children were taken and analyzed for urinary iodine excretion (UIE). A total of 29 soil samples and 87 water samples were taken from the study site to measure the concentration of iodine and heavy metals Hg, Pb, and Cd. Types of water source, altitude, and land use, both soil and water source were recorded.  Results. The median (min-max) UIE was 130 (14 –1187 µg/L) within the range of adequate population iodine intake according to WHO (100-199 µg/L), while the percentage of UIE <100 µg/L was still around 33.07 percent. The concentration of iodine in the soil was 33.777 mg/kg (6.640 –108.809), and the concentration of iodine in the water was 8.0 µg/L (0-49). The concentration of Hg in the soil was 68.64 ppb (7.43–562.05), and the concentration of Hg in the water was 0.00 ppb (0.00-23.24).  The concentration of Pb in the soil was 3.273 ppm (0.000–25.227), while Pb was not identified in the water. The Cadmium was not detectable both in the soil and water. Conclusion. Iodine deficiency is still a public health problem in Dayakan and Watubonang villages. The environment of the endemic IDD area in Ponorogo was not completely poor in iodine, but iodine was not evenly spread and mobilized. There was a risk of environmental heavy metal exposure from Hg in the soil or water and Pb in the soil. Mercury in the environment can cause health problems due to the inhibition of the use of iodine in the thyroid gland.

References

World Health Organization/UNICEF/ICCIDD. Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination: A Guide for Programme Managers. Third Edition. Geneva: WHO; 2007.

Zimmermann M. Key Barriers to Global Iodine Deficiency Disorder Control: A Summary. Technical Brief. Washington:USAID; 2007.

Bekele A, Adilo TM. Prevalence of Goiter and Its Associated Factors Among Primary School Children in Chole District. Arsi Zone. Ethiopia: A Cross Sectional Study. BMC Nutr. 2019;5(5):1–10.

Ahmad S, Bailey EH, Arshad M, Ahmed S, Watts M J, Stewart AG, et al. Environmental and Human Iodine and Selenium Status: Lessons From Gilgit-Baltistan North-East Pakistan. Environ Geochem Health. 2021;10 :1–22.

Dabaghmanesh M, Sadegholvaad A, Ejtehadi F, Omrani. The Role of Iron Deficiency In Persistent Goiter. Arch Iranian Med. 2008;11(2):157–161.

Abebe Z, Gebeye E, Taeriku A. Poor Dietary Diversity. Wealth Status and Use of Un-Iodized Salt are Associated with Goiter among School Children: A Cross-Sectional Study in Ethiopia. BMC Public Health. 2017;17(1):1–11.

Eastman CJ, Zimmermann MB. The Iodine Deficiency Disorders. [Updated 2018 Feb 6]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK285556/.

Hetzel BS. The Development of a Global Program for the Elimination of Brain Damage Due to Iodine Deficiency. Asia Pac J Clin Nutr. 2012;21(2):164–70.

Zimmermann MB, Jooste PL, Pandav CS. Iodine-Deficiency Disorders. The Lancet. 2008; 372(9645):1251–62.

Fuge R, Johnson CC. Iodine and Human Health. The Role of Environmental Geochemistry and Diet, A Review. Applied Geochemistry. 2015;63:282–302.

Thaha RA, Djunaidi MD, Nurhaedar J. Analisis Faktor Risiko Coastal Goiter. Jurnal GAKY Indonesia. 2002;1(1):9–20.

Sulchan M. Goiter in the Coastal Areas (Case in Pati Regency): An Ecological Nutritional Problem?. Jurnal GAKY Indonesia. 2002;6(1): 17–22.

Al-Rekabi AM, Habban HG. The Rate of Thyroid Tumor among Patients with Goiter Referred to Al-Diwaniyah Teaching Hospital. Indian J Public Health. 2018 Nov;9(11):391.

Guo J, Lv N, Tang J, Zhang X, Peng L, Du X, et al. Associations of Blood Metal Exposure with Thyroid Hormones in Chinese Pregnant Women: A Cross-Sectional Study. Environment International. 2018;121(2):1185–92.

Afrifa J, Ogbordjor WD, Duku-Takyi R. Variation in Thyroid Hormone Levels is Associated with Elevated Blood Mercury Levels Among Artisanal Small-Scale Miners in Ghana. PloS one. 2018;13(8):1–11.

Jancic SA, Stosic BZ. Cadmium Effects on the Thyroid Gland. Vitamins & Hormones. 2014;94:391–425.

World Health Organization/ World Bank/ Ministry of Health Indonesia. Iodine Deficiency in Indonesia: A Detailed Nationwide Map of Goitre Prevalence. Geneva: WHO; 2001.

Dinas Kesehatan Provinsi Jawa Timur. Profil Kesehatan Jawa Timur 2009. Surabaya: Dinas Kesehatan Provinsi Jawa Timur; 2009.

Rohmadheny, PS. Case Study of Early Childhood Special Needs in Sidoharjo Village. The 2nd International Proceeding of All Care for Children on Early Childhood Developmen; 12-13 Juni 2015;Surabaya : 2015.

Badan Pusat Statistik. Kabupaten Ponorogo Dalam Angka 2013. Ponorogo: BPS Ponorogo; 2013.

Fuge R, Long AM. Iodine in the Soils of North Derbyshire. Environ Geochem Health. 1989:11(1):25–29.

Dinkes Kab. Wonogiri. Laporan Kesehatan Kabupaten Wonogiri Tahun 2016. Wonogiri: Dinkes Kab. Wonogiri; 2016.

Musoddaq MA, Setyani A. Hubungan Kandungan Iodium dalam Air Tanah terhadap Ketinggian Tempat di Lereng Barat Gunung Merapi. MGMI.2011;2(2):123–27.

Smedley PL. Water Quality Fact Sheet: Iodine. British Geological Survey. 2000:1–4.

Johnson CC. The Geochemistry of Iodine and its Application to Environmental Strategies for Reducing the Risk from Iodine Deficiency Disorders (IDD). Technical Report:British Geological Survey; 2003.

Abe SS, Ashida K, Kamarudin KN, Kamil MI, Umami IM, Soil Micronutrient Availability as Affected by Land Use and Management in a Tropical Volcanic Mountain Area of West Sumatra, Indonesia. Trop. Agric. Dev. 2018;62(3):136–40.

Kementerian Kesehatan RI. Peraturan Menteri Kesehatan RI Nomor 492/MENKES/PER/IV/2010 Tentang Persyaratan Kualitas Air Minum. Jakarta: Kementerian Kesehatan; 2010.

Kementerian Kesehatan RI. Peraturan Menteri Kesehatan RI Nomor 32 Tahun 2017 Tentang Standar Baku Mutu Kesehatan Lingkungan dan Persyaratan Kesehatan Air Untuk Keperluan Higiene Sanitasi, Kolam Renang, Solus Per Aqua dan Pemandian Umum. Jakarta: Kementerian Kesehatan; 2017.

Driscoll CT, Mason RP, Chan HM, Jacob DJ, Pirrone N. Mercury as A Global Pollutant: Sources, Pathways, and Effects. Environ. Sci. Technol. 2013;47(10):4967–83.

Published
2021-12-06
How to Cite
1.
Musoddaq M, Hidayat T, Khimayah K. IODINE STATUS IN SCHOOL CHILDREN AND DISTRIBUTION OF IODINE, MERCURY, LEAD IN SOIL AND WATER IN THE ENDEMIC GOITER HILL AREA, PONOROGO. mgmi [Internet]. 6Dec.2021 [cited 29Mar.2024];13(1):1-0. Available from: http://ejournal2.litbang.kemkes.go.id/index.php/mgmi/article/view/5135