Perilaku Mikrofilaria Brugia timori dan Wuchereria bancrofti pada Kasus Filariasis dengan Infeksi Campuran di Kabupaten Sumba Barat Daya
The Behavior of Microfilariae Brugia timori and Wuchereria bancrofti in Filariasis Cases with Mixed Infection in Southwest Sumba Regency
Abstract
ABSTRACT
Brugia timori is a filariasis worm which distribution is limited in the East Nusa Tenggara Islands, while Wuchereria bancrofti is widespread almost all over the world. The density of microfilariae shows daily behavior that varies depending on the species of microfilariae. Cases of mixed infections between B. timori and W. bancrofti were reported in the Kahale Village, Southwest Sumba Regency. This study aims to determine the microfilariae periodicity of B. timori and W. bancrofti in filariasis patients with mixed infections. The Subjects in this study were five positive people with filariasis with mixed infections of W. bancrofti and B. timori. The Blood sampling was conducted 12 times in 24 hours with intervals of two hours, starting from 2:00 PM to midnight local time. Data were analyzed using Aikat and Das formula. The Circadian rhythm of microfilariae B. timori and W. bancrofti showed those cases had the circadian or harmonic wave. B. timori and W. bancrofti microfilaria had the same periodicity index (D) above 100%, with peak densities (K) both of microfilaria species in peripheral blood circulation, between 11:00 PM to 03:00 AM. The Behaviors of microfilariae B. timori and W. bancrofti in mixed infection cases were not different. The behavior of those microfilariae species was as nocturnal periodic.
ABSTRAK
Brugia timori merupakan cacing yang penyebarannya terbatas di Kepulauan Nusa Tenggara Timur, sedangkan Wuchereria bancrofti adalah mayoritas penyebab kasus filariasis limfatik di seluruh dunia. Kepadatan mikrofilaria menunjukkan perilaku harian berbeda-beda bergantung dari jenis mikrofilaria. Kasus infeksi campuran antara B. timori dan W. bancrofti dilaporkan terjadi di Desa Kahale, Kabupaten Sumba Barat Daya. Penelitian ini bertujuan untuk untuk mengetahui perilaku B. timori dan W. bancrofti pada penderita filariasis dengan infeksi campuran. Subjek dalam penelitian ini adalah lima orang positif infeksi campuran W. bancrofti dan B. timori. Pengambilan darah dilakukan 12 kali dalam rentang waktu 24 jam dengan interval dua jam, dimulai dari pukul 14.00 sampai pukul 12.00 waktu setempat. Analisis statistik yang digunakan dalam penentuan periodisitas mikrofilaria adalah formula Aikat dan Das. Ritme sirkadian (F) perilaku mikrofilaria B. timori dan W. bancrofti menunjukkan gelombang yang harmonik atau sirkadian. Mikrofilaria B. timori dan W. bancrofti mempunyai indeks periodisitas (D) yang sama diatas nilai 100%, dengan puncak kepadatan (K) kedua spesies mikrofilaria di peredaran darah tepi antara pukul 23.00 sampai pukul 03.00. Tidak ada perbedaan perilaku mikrofilaria B. timori dan W. bancrofti pada kasus infeksi campuran yaitu periodik nokturnal.
References
Juhairiyah J, Fakhrizal D, Hidayat S, Indriyati L, Hairani B. Kepatuhan Masyarakat Minum Obat Pencegah Massal Filariasis (Kaki Gajah): Studi Kasus Desa Bilas, Kabupaten Tabalong. J Vektor P e n y a k i t . 2 0 1 9 ; 1 3 ( 1 ) : 4 9 - 5 8 . doi:10.22435/vektorp.v13i1.956
Ambarita LP, Taviv Y, Sitorus H, et al. Komposisi Jenis Nyamuk di Beberapa Wilayah Endemis Penyakit Kaki Gajah di Kabupaten Banyuasin Provinsi Sumatra Selatan. Vektora . 2 0 1 7 ; 9 ( 2 ) : 6 9 - 7 8 . doi:10.22435/vk.v9i2.5471.69-78
Erlan A, Chadijah S, Udin Y. Persepsi Stakeholder Tentang Program Eliminasi Filariasis di Kabupaten Enrekang, Provinsi Sulawesi Selatan : Suatu Tinjauan Studi Kasus. J Vektor Penyakit. 2019;13(2):133-140. doi:10.22435/vektorp.v13i2.1097
Novita R. Dampak perubahan iklim terhadap timbulnya penyakit tular nyamuk terutama Limfatik Filariasis. J Helath Epidemiolgy C o m m u n D i s . 2 0 1 9 ; 5 ( 1 ) : 3 0 - 3 9 . doi:https://dx.doi.org/10.22435/jhecds.v5i1. 1583
Juhairiyah, Ridha MR, Fakhrizal D. Periodisitas Non Periodik Brugia Malayi di Kabupaten Tabalong. Vektora . 2017 ; 9 ( 2 ) : 79 - 86 . doi:10.22435/vk.v9i2.6322.79-86
Chadijah S, Srikandi Y. Perilaku mikrofilaria Brugia malayi pada subjek Filariasis di Desa Polewali Kecamatan Bambalamotu Kabupaten Mamuju Utara Sulawesi Barat. Aspirator. 2015;7(2):42-47.
World Health Organization. Lymphatic Filariasis: A Handbook of Practical Entomology for National Lymphatic Filariasis Elimination Programmes. Switzerland: WHO Press; 2013.
Shriram AN, Krishnamoorthy K, Vijayachari P. Diurnally subperiodic filariasis among the Nicobarese of Nicobar district - Epidemiology, vector dynamics & prospects of elimination. Indian J Med Res. 2015;141:598-607. doi:10.4103/0971-5916.159537
Sudjadi F, Hadianto T. Perilaku Mikrofilaria Brugia malayi dalam Darah Tepi Penderita Filariasis di Daerah Intergradasi Delta Mahakam, Kalimantan Timur. Berkala Ilmu Kedokteran. 2002;34(2):2002.
Harpini A. Menuju Indonesia Bebas Filariasis.
Pus Data dan Inf Kemenkes RI. 2018.
Dinas Keshatan Provinsi Nusa Tenggara Timur. Profil Kesehatan Provinsi Nusa Tenggara Timur 2017. Kupang; 2018.
Patanduk Y, Yunarko R, Mading M. Penerimaan Masyarakat dan Cakupan Pengobatan Massal Filariasis di Kecamatan Kodi Balaghar, Kabupaten Sumba Barat Daya. Bul Penelit Sist Kesehat. 2016;19(2):157-163.
Yunarko R, Patanduk Y. Distribusi Filariasis Brugia Timori dan Wuchereria Bancrofti di Desa Kahale, Kecamatan Kodi Balaghar, Kabupaten Sumba Barat Daya, Nusa Tenggara T i m u r. B a l a b a . 2 0 1 6 ; 1 2 ( 2 ) : 8 9 - 9 8 . doi:10.22435/blb.v12i2.4760.89-98
WHO. Monitoring and Epidemiological Assesment of the Programme to Eliminate Lymphatic Filariasis at Implementation Unit L e v e l . s w i t z e r l a n d ; 2 0 0 5 . http://www.searo.who.int/LinkFiles/New Lymphatic Filariasis OMSLFME Assessment.pdf.
Kazura J. Lymphatic Filarial Infections: An Introduction to The Filariae. In: Klei TR, Rajan T, eds. World Class Parasites: Volume 5 The Filaria. USA: Kluwer Academic Publishers; 2002:9-19.
Aikat TK, Das M. A modified statistical method for analysis of periodicity of microfilaria. Indian J Med Res. 1977;65(1):58-64.
Supali T, Wibowo H, Ruckert P, et al. High Prevalence of Brugia Timori Infection in The Highland of Alor Island, Indonesia. Am J Trop Med Hyg. 2002;66(5):560-565.
Supali T, Djuardi Y, Lomiga A, et al. Comparison of the Impact of Annual and Semiannual Mass Drug Administration on Lymphatic Filariasis Prevalence in Flores Island, Indonesia. Am J Trop Med Hyg. 2019;100(2):336-343. doi:10.4269/ajtmh.18-0570
Erickson SM, Xi Z, Mayhew GF, et al. Mosquito Infection Responses to Developing Filarial Worms. PLoS Negl Trop Dis. 2009;3(10):1-11. doi:10.1371/journal.pntd.0000529
Hairston NG, Meillon BDE. On the Inefficiency of Transmission of Wuchereria bancrofti from Mosquito to Human Host. Bull World Health Organ. 1968;36(6):935-941.
Ramadhani T, Hadi UK, Soviana S, Irawati Z. Transmisi Strain Wuchereria Bancrofti Perodik Nokturnal Oleh Culex quinquefasciatus Di Kota Pekalongan. Acta Vet I n d o n e s . 2 0 1 9 ; 7 ( 2 ) : 1 - 8 . doi:10.29244/avi.7.2.1-8
Cabral PC, Olivier M, Cermakian N. The Complex Interplay of Parasites, Their Hosts, and Circadian Clocks. Front Cell Infect M i c r o b i o l . 2 0 1 9 ; 9 : 1 - 8 . doi:10.3389/fcimb.2019.00425
Manguin S, Bangs MJ, Pothikasikorn J, Chareonviriyaphap T. Review On Global o- transmission of human Plasmodium species and Wuchereria bancrofti by Anopheles mosquitoes. Infect Genet Evol. 2010;10:159- 177. doi:10.1016/j.meegid.2009.11.014
. Santoso, Suryaningtyas NH. Spesies Mikrofilaria Pada Penderita Kronis Filariasis Secara Mikroskopis dan Polymerase Chain Reaction di Kabupaten Tanjung Jabung Timur. Media Litbangkes. 2015;25(4):249-256.
Tuti S, Ronny A, Ekowatiningsih R. Masalah Filariasis di Kabupaten Sikka, Provinsi Nusa Tenggara Timur (NTT). Bull Penelit Kesehat. 2009;37(4):169-179.
Adnyana NWD, M . Laumalay H, Tallan MM. Penentuan Nyamuk Anopheles spp sebagai Vektor Filariasis di Kabupaten Sumba Timur dan Sumba Barat Provinsi Nusa Tenggara Timur. Media Penelit dan Pengemb Kesehat.
0 1 9 ; 2 9 ( 2 ) : 1 7 7 - 1 8 8 . doi:10.22435/mpk.v29i2.281
Reece SE, Prior KF, Mideo N. The Life and Times of Parasites: Rhythms in Strategies for Within- host Survival and Between-host Transmission. J Biol Rhythms . 2017; 32( 6): 516- 533. doi:10.1177/0748730417718904
Schroeder JH, McCarthy D, Szestak T, et al. Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner. PLoS Negl Trop Dis. 2017;11(5):1-22. doi:10.1371/journal.pntd.0005592
Supranelfy Y, Ritawati, Oktarina R. Periodisitas Mikrofilaria Brugia malayi Dalam Darah di Kabupaten Muaro Jambi . Spirakel . 2019;11(1):17-23.
Anorital, Dewi RM, Roselinda, Maha MS, Indiarto AH, Hendrik. Status Antibodi Filariasis Penduduk Pasca Pemberian Obat Pencegah Massal (POPM) Secara Menyeluruh dan Parsial di Wilayah Endemis Filariasis. J Biotek Medisiana Indones. 2016;5(1):31-39.
Tallan MM, Mau F. Karakteristik Habitat Perkembangbiakan Vektor Filariasis di Kecamatan Kodi Balaghar Kabupaten Sumba Barat Daya. ASspirator. 2016;8(2):55-62. doi:10.22435/aspirator.v8i2.4243.55-62
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