Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin

  • Febia Arien Lestari Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
  • Wahida Hajrin Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
  • Nisa Isneni Hanifa Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
Keywords: Katuk leave, Cream, Simplex Lattice Design, Design Expert

Abstract

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.

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Published
2020-08-24
How to Cite
1.
Lestari F, Hajrin W, Hanifa N. Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin. jki [Internet]. 24Aug.2020 [cited 20May2022];10(2):110-9. Available from: https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/2496
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