Karakterisasi Kompleks Inklusi Asam Mefenamat - B-Siklodekstrin yang Dibuat dengan Metode Freeze Drying

  • Dwi Setyawan Departemen Farmasetika Fakultas Farmasi Universitas Airlangga
  • Dewi Isadiartuti Departemen Farmasetika Fakultas Farmasi Universitas Airlangga
Keywords: mefenamic acid, freeze drying, inclusion complex, dissolution rate

Abstract

Characterization of mefenamic acid- ,8-cyclodextrin inclusion complexes by freeze dryin method had been studied. Solid state mefenamic acid - B-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamlc acid, B-cyclodextrin, mefenamic acid - B-cyclodextrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscop (FTIR) , Dijferential Thermal Analyzer (DT/1) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and B-lcyclodextrin. In vitro dissolution rate studies of mefenamic acid, mefenamic acid - B-lcyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid - B-lcyclodextrin inclusion complex showed increasing dissolution rate compared to me?znamic acid - B-cyclodextrin physical mixture and mefenamic acid.

References

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Published
2009-02-24
How to Cite
1.
Setyawan D, Isadiartuti D. Karakterisasi Kompleks Inklusi Asam Mefenamat - B-Siklodekstrin yang Dibuat dengan Metode Freeze Drying. jki [Internet]. 24Feb.2009 [cited 27Oct.2020];1(1):1-. Available from: https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/2837
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Articles