Uji Bioavailabilitas Tablet Floating Aspirin

  • Agus Siswanto Fakultas Farmasi Universitas Muhammdiyah Purwokerto, Purwokerto, Indonesia
  • Achmad Fudholi Fakultas Farmasi Universitas Gadjah Mada, Indonesia
  • Akhmad Kharis Nugroho Fakultas Farmasi Universitas Gadjah Mada, Indonesia
  • Sudibyo Martono Fakultas Farmasi Universitas Gadjah Mada, Indonesia
Keywords: Bioavailability, Floating tablets, Aspirin


Aspirin is a non-steroidal anti-inflammatory drug with potential as antiplatelet for stroke prophylaxis. Several approaches of aspirin formulations in various dosage forms have been performed. Formulations of aspirin in conventional tablet dosage form often cause gastric irritation. Aspirin is rapidly absorbed in the upper gastrointestinal tract, especially the first small intestine. Therefore formulation of floating drug delivery system are designed to improve the bioavailability of aspirin. The floating system will retain the tablet in stomach, allowing sufficient absorption time for aspirin in stomach and upper intestine. Aim of this study was to determine relative bioavailability of aspirin floating tablets compared to the aspirin enteric coated tablets in rabbits with crossover design method. Serial blood samples were collected from rabbit ear marginal vein over a 10-h period. Drugs concentration in plasma (aspirin and salisylic acid) were determined by HPLC with benzoic acid as internal standard. The results showed that the floating aspirin tablet has better bioavailability with shorter tmax and more uniform of aspirin levels compared to enteric coated tablets, though the parameters AUC and Cpmax both of those products were not significant (p> 0.05).


Lauer MS. Aspirin for primary prevention of coronary events. N Engl J Med. 2002; 346(19):1468-74.

Awtry EH, Loscalzo J. Aspirin. Circulation. 2000;101:1206-18.

Patrono C, Rocca B. Aspirin: promise and resistance in the new millennium. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:s25-s32.

Kannan S, Manivannan R, Balasubramaniam A, Kumar NS. Formulation and evaluation of aspirin delayed release tablet. International Journal of Comprehensive Pharmacy. 2010;1(4):1-3.

Mason PJ, Jacobs AK, Freedman JE. Aspirin resistance and atherothrombotic disease. J.Am.Coll.Cardiol. 2005;46:986-93.

Sweetman SC, Editor. Martindale the complete drug reference. Thirty-sixth ed. London: Pharmaceutical Press; 2009.

McEvoy, G.K, editor. AHFS drug information. Bethesda USA: American Society of Health-System Pharmacist; 2002.

Suratri A. Floating drug delivery systems to increase gastric retention of drugs: a review. RJPT. 2008;1(4).

Siswanto A, Fudholi A, Nugroho AK, Martono S. In vitro release modeling of aspirin floating tablets using DDSolver. Indonesian J. Pharm. 2015;26(2):94-102.

Shargel L, Yu ABC. Applied biopharmaceutics and pharmacokinetics, 4th Ed., New York: Appleton & Lange; 1999.

Bamigbola EA, Ibrahim MA, Attama AA, Arute JE. Comparative bioequivalence assessment of aspirin tablets marketed in nigeria. Int J Health Res. 2009;2(4):375-9.

Siswanto A, Fudholi A, Nugroho AK, Martono S. Validasi Metode HPLC untuk Penetapan Kadar Aspirin dan Asam Salisilat dalam Plasma Kelinci (Lepus curpaeums) Secara Simultan. Jurnal Kefarmasian Indonesia. 2016;6(2):68-78.

Gopalakrishnan S, Chenthilnathan A. Floating drug delivery systems: a review. Journal of Pharmaceutical Science and Technology. 2011;3(2):548-54.

Moffat AC, Osselton MD, Widdop B, Watts J, editor. Clarke’s analysis of drugs and poisons in pharmaceuticals, body fluids and postmortem material. Fourth edition. London-Chicago: Pharmaceutical Press; 2011.

Siswanto A, Fudholi A, Nugroho AK, Martono S. Pengaruh Medium Dissolusi dan Penggunaan Sinker Terhadap Profil Disolusi Tablet Floating Aspirin. PHARMACY. 2014:11(02):218-31.

Pandey S, Devmurari V, Paridhi S, Mahalaxmi R. Development and in Vitro Evaluation of Propranolol Hydrochloride Based Gastro-Retentive Floating Tablet. Der Pharmacia Lettre. 2010(2):75-86.

Collett J, Moreton C. Modified-release peroral dosage form. in Aulton ME. Pharmaceutics:the science of dosage form design. Ed. II. Edinburg: Churchill Livingstone; 2002.

How to Cite
Siswanto A, Fudholi A, Nugroho A, Martono S. Uji Bioavailabilitas Tablet Floating Aspirin. jki [Internet]. 22Aug.2017 [cited 9Dec.2022];7(2):112-9. Available from: https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/3498