Formulasi Tablet Salut Selaput Katekin dari Ekstrak Gambir (Uncaria gambir Roxb.)

  • Arifayu Addiena Kurniatri Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Indonesia
  • Rosa Adelina Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Indonesia
  • Herni Asih Setyorini Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Indonesia
  • Indah Sulistyowati Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Indonesia
Keywords: Film coated tablet, Catechin, Uncaria gambir

Abstract

Gambir extract contains a high content of catechin. Catechin has so many benefits, such as antioxidant, antimicrobial, and anti-atherosclerosis.Gambir are widely available in Indonesia, especially in West Sumatra, might be a sustainable source of catechin. Catechin is easily oxidized and hygroscopic. Film coating is used to protect catechin contained in a tablet from moisture and light. Study of film-coated tablet of catechin has not been conducted before. This study aims to formulate film-coated tablet of catechin from gambir and evaluate its physical properties. Catechin was percolated from gambir extract using ethyl astetat. The ethyl acetate fraction of gambir extract contains 92,48±0,28% catechin. Tablets were compressed with direct compression method and coated with a polymer coating material. The physical properties of core tablet and film-coated tablet were evaluated toward weight uniformity, hardness, friability, and disintegration time. Friability testing was conducted only on core tablet. The formulation produced tablets with uniform weight, 16,6 ±1,97 Kp hardness, and 4 minutes 15 seconds disintegration time. Weight uniformity and disintegration time of the tablet meet the requirements.

References

Anggraini T, Tai A, Yoshino T, Itani T. Antioxidative activity andcatechin content of four kinds of Uncaria gambir extracts from West Sumatra, Indonesia. African J Biochem Res. 2011; 5(1):33-8.

Yunarto N, Elya B, Konadi L. Potensi fraksi etil asetat ekstrak daun gambir (Uncaria gambir, Roxb.) sebagai antihiperlipidemia. Jurnal Kefarmasian Indonesia, 2015;5(1):1-10.

Sulistyaningrum N, Rustianti L, Alegantina S. Uji mutagenik Ames untuk melengkapi data keamanan ekstrak gambir (Uncaria gambir, Roxb). Jurnal Kefarmasian Indonesia. 2013; 3(1):36-45.

Rahmawati N, Bakhtiar A, Putra DP. Isolasi katekin dari gambir (Uncaria gambir (Hunter). Roxb ) untuk sediaan farmasi dan kosmetik. J Penelit Farm Indones. 2012; 1(1):6–10.

Kassim MJ, Hussin MH, Achmad A, Dahon NH, Suan TK, Hamdan HS. Determination of total phenol, condensed tannin and flavonoid contents and antioxidant activity of Uncaria gambir extracts. Majalah Farmasi Indonesia. 2011; 22(1):50–9.

Auclair S, Milenkovic D, Besson C, Chauvet S, Gueux E, Morand S, et.al. Catechin reduces atherosclerotic lesion development in apo E-deficient mice: A transcriptomic study. Atherosclerosis. 2009; 204(2):21–7.

Mittal A, Pate MS, Wylie RC, Tollefsbol TO, Katiyar SK. EGCG down-regulates telomerase in human breast carcinoma mcf-7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol. 2004; 24(3):703–10.

Weyant MJ, Corothers AM, Dannenberg AJ, Bertagnolli MM. (+)-catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. 2001. Cancer Res. 2001; 61(1):118–25.

Murase T, Haramizu S, Ota N, Hase T. Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated Mice. Am J Physiol Requl Integr Comp Physiol. 2008; 295:281–89.

Chabib L, Triastuti A, Irianti RD. Formulasi tablet hisap ekstrak gambir (Uncaria gambir (Hunter) Roxb.) dengan variasi bahan pengikat gom arab (Gummi acaciae). Majalah Obat Tradisional. 2010; 15(2):75–79.

Ansel HC. Pengantar bentuk sediaan farmasi. Edisi IV. Jakarta: Penerbit Universitas Indonesia (UI-Press). 662 hlm. 1989.

Burke MD, He X, Cook C, Petrov GA, Long S, Coffin MD. Stability enhancement of drug layered pellets in a fixed dose combination tablet. AAPS Pharm Sci Tech. 2013; 14(1):312–20.

Devi VG, John A, Devi RS, Prabhakaran VA. Pharmacognostical studies on Acacia catechu Willd and identification of antioxidant principles. Int J Pharm Pharm Sci. 2011; 3(2):108-111.

Sensitive determination of catechins in tea by HPLC [Internet]. 2011 May 19 [cited 2014 Mar 27]. Available from: (http://www.dionex.com /en-us/webdocs/110783-AN275-HPLC-Catechins-Tea-19May2011-LPN2799.pdf,

Farmakope Herbal Indonesia. Edisi I. Jakarta: Dirjen Pelayanan Farmasi dan Alat Kesehatan. 2008.

Farmakope Indonesia. Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia. 1995.

Nasrin N, Asaduzzaman M, Mowla R, Alam A. A comparative study of physical parameters of selected ketorolac tromethamine tablets. The Pharma Market of Bangladesh. J Appl Pharm Sci. 2011; 01(08):101–3.

Yunarto N. Formulation of Peperomia pellucida (L) Kunth extract tablet . Health Science Journal of Indonesia. 2013;4(1):32-6.

Published
2015-08-31
How to Cite
1.
Kurniatri AA, Adelina R, Setyorini HA, Sulistyowati I. Formulasi Tablet Salut Selaput Katekin dari Ekstrak Gambir (Uncaria gambir Roxb.). jki [Internet]. 31Aug.2015 [cited 20May2022];5(2):83-9. Available from: https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/3688
Section
Articles