Risiko Penggunaan ACEi Terhadap Kejadian Batuk Kering pada Pasien Hipertensi di RSUD Cengkareng dan RSUD Tarakan DKI Jakarta
AbstractThe use of angiotensin converting enzyme inhibitors (ACEi) as an antihypertensive agent can cause side effects such as dry cough. The aim of this study is to evaluate risk of ACEi administration on dry cough incidence with captopril as the standard against lisinopril and ramipril in hypertensive patients at RSUD Cengkareng and RSUD Tarakan Jakarta. The design of this study is prospective cohort. The inclusion criteria were patients who received ACEi as hypertension therapy for ≤ 3 months gathered from outpatient and willing to participate as sample in this study at RSUD Cengkareng and RSUD Tarakan. Subject of this study consist of 54 patients who received captopril and 54 patients received non captopril ACEi, taken by consecutive sampling from January-July 2014. Data was collected using structured interviews and medical record. Dry cough incidence due to ACEi was evaluated using Naranjo Algorithm and analyzed using Chi Square test. Dry cough incidence was found in 19,44% of sample. No significant relationship of age, gender, ethnic, comorbidity, body mass index (BMI), dosage, and duration of use with the dry cough incidence due to the use of ACEi. There is no difference on dry cough incidence between the use of captopril, lisinopril and ramipril.
WHO. A Global Brief On Hypertension: Silent Killer, Global Public Health Crisis. Switzerland: WHO; 2013:9-15.
Rahajeng E, Tuminah S. Prevalensi Hi-pertensi dan Determinannya di Indonesia.MKI. 2009;59(12):580-7
Kemenkes RI. Penyakit Tidak Menular. Kementerian Kesehatan Republik Indonesia Semester II 2012. ISSN 2088-270X.
Amir M, Khan B, Tahir M. Incidence of Angiotensin Converting Enzyme Inhibitor Induce Cough. Professional Med J. 2005;12(4):435-9.
James PA, Oparil S, Carter BL, Cushman WC, Himmelfarb CD, Handler J, et al. Evidence-Based Guideline For The Management of High Blood Pressure in Adults: Report From The Panel Members Appointed To The Eighth Joint National Committee (JNC 8). JAMA. 2013.
Zamora SG, Parodi R. Cough and Angioedema in Patients Receiving Angiotensin-Converting Enzyme Inhibitors. Are They Always Attributable to Medication? Argent Cardiol. 2011;79:157-63.
Prasad BG, Kumar VR, Ram VR, Mohanta GP, Manna PK. A Study of Adverse Drug Reactions Due To Antihypertensive Drugs in a Tertiary Care Teaching Hospital. IJPLS. 2011; 2(5):767-72.
Li FY, Zhu M, Liu F, Xiao CS, Bian YF, Li H, et.al. Angiotensin-Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism and ACE Inhibitor-Related Cough: A Meta-Analysis. PLos ONE. 2012; 7(6):373-96.
Aziza L, Sja’bani M, Haryana SM, Soesatyo M, Sadewam AH. Hubungan Polimorfisme Gen Angiotensin-Converting Enzyme Insersi/Delesi dengan Hipertensi pada Penduduk Mlati, Sleman, Yogyakarta, Indonesia. MKI. 2010; 60(4):156-62.
Rossi P, Francès Y, Kingwell BA, Ahimastos AA. Gender Differences in Artery Wall Biomechanical Properties Throughout Life. J Hypertens. 2011;29:1023–33.
NHS. Hypertension. Clinical Mana-gement of Primary Hypertension in Adults. London: National Institute for Health and Clinical Excellence. 2011;5.
Low S, Chin MC, Ma S, Heng DM, Deurenberg Y. Rationale for Redefining Obesity in Asians. AAMS. 2009;38:66-74.
Opie LH, Pfeffer MA. Inhibitors of Angiotensin-Converting Enzyme, Angio-tensin II Receptor, Aldosterone, and Renin. Drugs For The Heart 7th Edition.Philadelphia: Saunders; 2009.
Lacy CF, Amstrong LL, Goldman MP, Lance LL. Drug Information Handbook 20th Edition. Amerika Utara: Lexi-Comp; 2011.
Dicpinigaitis PV. Angiotensin-Converting Enzyme Inhibitor Induced Cough: ACCP Evidence Based Clinical Practice Guidelines. Chest. 2006;129:169-73.
Walker R, Whitlesea C. Clinical Pharmacy and Therapeutics 4th Edition; 2007.
Salami AK, Katibi IK. Angiotensin Converting Enzyme- Inhibitors Associated Cough: A Prospective Evaluation in Hypertensives. Annalsafrmed. 2005;4(3):118-21.
Omboni S, Borghi C. Zofenopril and Incidence of Cough: A Review of Published and Unpublished Data. Ther Clin Risk Manag. 2011;7:459-71.
Azimivaghar J, Javadirad E. Incidence of Captopril-Induced Cough in Newly Diagnosed Hypertensive Patients: Incidence in an Outpatient Medical Clinic Population in Iran in 2011-2012. JCTM. 2014;2(3):193-97.
Singh H, Marrs JC. Heart Failure. Koda-Kimble & Young Applied Therapeutics The Clinical Use of Drugs Tenth Edition. USA: Lippincott Williams & Wilkins; 2013.
Nishio K, Kashiki S, Tachibana H, Kobayashi Y. Angiotensin-Converting Enzyme and Bradykinin Gene Polymorphisms and Cough: A Meta-Analysis. WJC. 2011;3(10):329-36.
Adams RJ, Appleton SL, Wilson DH, Taylor AW, Ruffin RE. Association of Physical and Mental Health Problems With Chronic Cough in a Representative Population Cohort. Cough. 2009;5(10):1-9.
Chatterjee NA, Fifer MA. Heart Failure. Pathophysiology of Heart Disease 5th Edition. Philadelphia: Wolters Kluwer; 2011.
Irwin RS. Chronic Cough Due to Gastroesophagel Reflux Disease: ACCP Evidence-Based Clinical Practice Guidelines. Chest. 2006;129:80-94.
Tumanan-Mendoza BA, Dans AL, Villacin LL, Mendoza VL, Rellama-Black S, Bartolome M, et al. Dechallenge and Rechallenge Method Showed Different Incidences of Cough Among Four ACE-Is. J Clin Epidemiol. 2007;60:547-53.
Al-Youzbaki WB, Mahmood IH. Prevalence of Captopril Induced Cough in Mosul Hypertensive. Iraqi J Comm Med. 2006;2:225-7.
Woo KS, Nicholls MG. High Prevalence of Persistent Cough Wish Angiotensin Converting Enzyme Inhibitor in Chinese. Br J Clin Pharmacol. 1995;40:141-4.
Rajeev K, Ramji S, Khemraj B, Ram KR, Arun K, Atul B. Modern Development in ACE inhibitors. DPL. 2010;2(3),388-419.
Sani Y, Tata F, Abdulganiyu G, Jamilu M, Tom MG. Evaluation of The Relative Incidence of Adverse Effects Leading to Treatment Discontinuation of Recommended Antihypertensive Drugs. IRJP. 2013;4(6),58-61.
Dinicolantonio JJ, Lavie CJ, O’Keefe JH. Not All Angiotensin-Converting Enzyme Inhibitors Are Equal: Focus on Ramipril and Perindopril. PMJ. 2013; 125:1941-9260:1-15.
Mutolo D, Cinelli E, Bongianni F, Evangelista S, Pantaleo T. Comparison Between The Effect of Lisinopril and Losartan on The Cough Reflex in Anesthetizied and Awake Rabbits. JPP. 2013;64(2):201-10.
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