Jurnal Kefarmasian Indonesia https://ejournal2.litbang.kemkes.go.id/index.php/jki <p>ISSN media elektronik:&nbsp;<a href="http://u.lipi.go.id/1387251248">2354-8770</a></p> <p>ISSN media cetak:&nbsp;<a href="http://u.lipi.go.id/1329660553">2085-675X</a></p> <p>Acredited by Kemenristek/BRIN Accreditation 200/M/KPT/2020 Sinta 2 Valid until Volume 15 Number 1, 2025</p> <p>Jurnal Kefarmasian Indonesia is a scientific journal published by Center for Health Resilience and Resource Policy, Ministry of Health Republic of Indonesia. The journal publishes conceptual thinking or ideas pharmacy policy and original articles in pharmaceutical science such as Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines and Pharmaceutical Care. The journal is published in Bahasa Indonesia and English. Jurnal Kefarmasian Indonesia is a biannual, open access, peer-reviewed and online pharmacy journal. Jurnal Kefarmasian Indonesia aims to serve the updated scientific knowledge for processing manuscript as well as for processing manuscript.</p> <p>Jurnal Kefarmasian Indonesia has been indexed by <a href="https://doaj.org/toc/2354-8770?source=%7B%22query%22%3A%7B%22filtered%22%3A%7B%22filter%22%3A%7B%22bool%22%3A%7B%22must%22%3A%5B%7B%22term%22%3A%7B%22index.issn.exact%22%3A%222085-675X%22%7D%7D%2C%7B%22term%22%3A%7B%22index.issn.exact%22%3A%222354-8770%22%7D%7D%2C%7B%22term%22%3A%7B%22_type%22%3A%22article%22%7D%7D%5D%7D%7D%2C%22query%22%3A%7B%22match_all%22%3A%7B%7D%7D%7D%7D%2C%22from%22%3A0%2C%22size%22%3A100%7D">DOAJ</a>; <a href="http://isjd.pdii.lipi.go.id/index.php/public_no_login/index_direktori">Indonesian Scientific Journal Database</a>, <a href="http://id.portalgaruda.org/?ref=browse&amp;mod=viewjournal&amp;journal=4889">Indonesian Publication Index</a>, <a href="https://www.base-search.net/Record/1497b5f9cf595ef0ff1193d5afab7b2f432efcff10643f42eacaf41a5aa3aa83/">Bielefeld Academic Search Engine</a>, <a href="http://oaji.net/journal-detail.html?number=825">Open Academic Journal Index</a>; <a href="https://scholar.google.co.id/citations?user=gASqT4MAAAAJ&amp;hl=en">Google Scholar</a>; <a title="Sinta" href="http://sinta2.ristekdikti.go.id/journals/detail?id=2785">Sinta</a> Garda Rujukan Digital (<a href="http://garuda.ristekdikti.go.id/journal/view/4889">Garuda</a>). See Google Scholar Profile for Jurnal Kefarmasian Indonesia by clicking <a href="https://scholar.google.co.id/citations?user=gASqT4MAAAAJ&amp;hl=en">here</a>.</p> 16 articles of Jurnal Kefarmasian Indonesia has been cited by Scopus. Click <a href="https://drive.google.com/file/d/1cbuQQ_DqFRVjLEgX09LY91s3rkZfL3lI/view?usp=sharing" target="_blank" rel="noopener">&nbsphere</a> for detail (update January 01, 2021). <p>Total citations: 1879</p> <p>Total documents: 136</p> <p>h-index: 21&nbsp; &nbsp; &nbsp;i10-index: 53&nbsp; &nbsp; &nbsp;Impact Factor: 12,06</p> <p>Rejection rate: 74.6%</p> Pusat Kebijakan Sistem Ketahanan Kesehatan dan Sumber Daya Kesehatan en-US Jurnal Kefarmasian Indonesia 2085-675X Aktivitas Antiparkinson Ekstrak dan Fraksi Buah Kemukus (Piper cubeba L.) pada Tikus Putih Galur Sprague Dawley https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5964 Pathophysiologies underlying the Parkinson's disease is oxidative stress, can be treat with antioxidants from natural sources, including Piper cubeba L. Flavonoids are reported as antioxidants. This study aimed to analyse the flavonoids content and antiparkinson activity from the ethanolic extract of cubeb fruits (EECF), ethyl acetate fraction of ethanolic extract of cubeb fruits (EAFEECF), n-hexane fraction of ethanolic extract of cubeb fruits (NHFEECF). This research is an experimental study with a post test only control group design. Eighty four rats were divided into 14 groups. Group 1 is a normal group, group 2-3 are negative controls which were given aquadest and olive oil, respectively. Positive control groups, 4 and 5 were given levodopa 27 mg/kgBW and vitamin E 180 IU/kgBW, respectively. Group 6-14 were given EECF, EAFEECF, and NHFEECF at doses 150, 300, 600 mg/kgBW. Group 2-14 were induced with haloperidol 2 mg/kgBW intraperitoneally 45 minutes after administration of the material tests. The materials are given once a day for 7 days. The length of time the rats can hold on to the rotarod was tested on days 0, 4, 7, 11, 14. The curve showed the data on the survival time of rats on a rotarod versus time, then the AUC0-14 was calculated using the trapezoidal method. The AUC0-14 were analyzed using Mann Whitney test at 95%CI. The flavonoids content were analysed using TLC. The results showed that the EECF, EAFEECF, and NHFEECF contained flavonoids, and antiparkinson activity except for the NHFEECF at doses 150 and 600 mg/kgBW. Kiki Damayanti Yance Anas Windy Marlina Talcha Nabila Putri Irmawati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-30 2022-08-30 90 98 10.22435/jki.v0i0.5964 Isolasi dan Skrining Aktivitas Antibakteri Fungi Tanah Muara Desa Katialada Gorontalo Lokasi Satu terhadap Staphylococcus aureus https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5978 The emergence of antibiotic resistance becomes a barrier in controlling infectious diseases, so it is necessary to find new alternative antibiotics. This study aimed to explore the potential of estuarine soil fungals secondary metabolites isolated from Katialada Village Gorontalo Location One and test their antibacterial activity against Staphylococcus aureus. The antibacterial parameter observed was the percent inhibition of ethyl acetate extracts against Staphylococcus aureus. The estuarine soil samples were cultured in PDA media producing five single fungal isolates differentiated based on color morphology, texture, and shape coded IS2-BTG-4.1.1, IS2-BTG-4.1.2, IS1-BTG-4.2, IS2-BTG4.3.1, and IS2-BTG-4.3.2. Those five samples were fermented using PDB media and the fermented products were extracted with ethyl acetate. The extracts were screened for its compound using a TLC plate and antibacterial testing with a single concentration of 100 g/mL in the microdilution method. The screening results showed that the five ethyl acetate extracts contained terpenoid compounds and code IS2-BTG-4.3.2 also had alkaloids. Based on the antibacterial test results, the five ethyl acetate extracts had growth inhibitory activity on the Staphylococcus aureus, with the percentage showed by IS2-BTG-4.1.1 50,2% ± 14,8%, IS2-BTG-4.1.2 35,6% ± 12,9%, IS1-BTG-4.2 13,0% ± 7,3%, IS2-BTG-4.3.1 13,6% ± 6,0%, and IS2-BTG-4.3.2 by 12,4% ± 9,2%. Wilda Nur Rohmatillah Muhammad Zainul Arifin Saeful Akhmad Tauladani Gani Asri Muharam Asia Asia Dwi Koko Pratoko Ari Satia Nugraha ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-31 2022-08-31 99 108 10.22435/jki.v0i0.5978 Formulasi Sediaan Minuman Serbuk Fungsional Kombinasi Biji Jagung (Zea mays L. ) dan Madu https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5536 Corn is a food ingredient that contains carotenoids that are very potential in preventing cancer, adding endurance, as antivirals, fungi, and parasites, carotenoids are also good for vision, growth and reproduction. The highest carotenoid compound in corn is lutein which has potential as an immunomodulator. Honey is also immunomodulatory by triggering macrophages to produce cytokines involved in killing bacteria and tissue repair. The combination of corn and honey in one drink will produce a health supplement preparation that contains antioxidants and immunomodulators that are good for health. The goal of this study was to get the best formula of instant granules physically. Instant granules are made from corn kernels that have been dried with a combination of honey which is processed by dry granulation with variations of corn kernels FI & FIV (15%), FII & FV (25%), FIII & FVI (35%), and FI & FIV honey (35%), FII & FV (25%), FIII & FVI (15%). Instant granules are conducted physical test evaluations including organoleptic tests, flow time, angle of repose, compressibility index, time of granules to dissolve, particle distribution, pH, viscosity of reconstituted and RDA test. The results showed that the granule flow time, angle of repose, compressibility index, time of granules to dissolve, granules particle distribution and viscosity of reconstituted overall physical testing showed no noticeable differences, except against the most preferred taste parameters FVI. So the best formulation has obtained is FVI and shows the result of the RDA test with total energy of 350 kcal/100 grams. Sheila Meitania Utami Nurwulan Adi Ismaya Tri Okta Ratnaningtyas Nanang Yunarto ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-26 2022-08-26 109 117 10.22435/jki.v0i0.5536 Ekstrak Etanol Ubi Jalar Ungu untuk Mencegah Peningkatan pH Vagina setelah Ovariektomi Bilateral pada Tikus Wistar https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5641 AVaginal atrophy is one of the most common health problems in postmenopausal women. The disease is characterized by decreasing layers and maturation index of the vaginal epithelium and an increase in vaginal pH. A decrease in vaginal acidity will increase the susceptibility to infections since acidic pH protects the vagina from pathogens infection. The previous study has proven that phytoestrogens were effective to improve the microstructures of the vaginal, reduce urogenital complaints, and improve vaginal pH. The purple sweet potato (Ipomea batatas L.) which is cultivated in Bali was recognized for its high anthocyanin content and was reported to have phytoestrogen activity. The aim of the present study is to evaluate the effect of purple sweet potato on vaginal pH in an animal model of menopause. The randomized pre-test post-test control group design study was conducted using 36 bilateral ovariectomized female Wistar rats as an animal model of menopause. The animals were divided randomly into a control group (T0) which was given saline and a treatment group (T1) given an ethanolic extract of purple sweet potato 400 mg/day for 30 days. Vaginal pH was measured before treatment, every week during treatment, and after treatment. The result of the study showed that there was an increase in vaginal pH of the T0 on the 2nd and 3rd week, and after treatment (P<0.05), compared to T1. In conclusion, the ethanol extract of purple sweet potato was effective to prevent an increase vaginal pH following ovariectomy in wistar rats. I Wayan Sugiritama I Gusti Nyoman Sri Wiryawan Ni Made Linawati Ida Ayu Ika Wahyuniari I Gusti Ayu Dewi Ratnayanthi I Gusti Nyoman Kamasan Arijana ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-30 2022-08-30 118 127 10.22435/jki.v0i0.5641 Tingkat Pengetahuan Masyarakat tentang Obat Tradisional setelah Pemberian E-Booklet di Kabupaten Karimun https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5950 Knowledge of traditional medicine is important for the formation of a person's activity in using traditional medicine. Preliminary studies conducted show the level of public knowledge about traditional medicine in the less category. This can be caused by a lack of desire to seek information and lack of education from health workers. For this reason, educational media such as e-booklets are needed. This study aims to see the level of public knowledge about traditional medicine after being given an e-booklet. This study uses a preexperimental method with a one group pretest-posttest design. The population of this research is the residents of Karimun Regency who have used traditional medicine. The sample of this study was 150 respondents who were determined using purposive sampling method. The inclusion criteria for the study were that the respondent was at least 18 years old, had used traditional medicine with the logo and was registered with BPOM for at least the last 3 months, could use a smartphone and was willing to be a respondent. The research instrument is e-booklet media and knowledge questionnaire. The knowledge questionnaire used has been tested for validity and reliability (obtained 20 valid questions with an r value of 0.881). Uni-variate data analysis to describe the level of knowledge and bi-variate analysis was carried out for the analysis of changes in pretest and post-test knowledge scores using the Wilcoxon test. The results obtained before giving the e-booklet are good knowledge as much as 6.6%, sufficient as much as 55.4% and less as much as 38% while after being given the e-booklet the knowledge of respondents with good category is 55.4%, enough is 38% and less as much as 6.6%. Bi-variate analysis obtained p value 0.000. It can be concluded that the given media has a significant effect on respondents knowledge. Ratna Sari Dewi Putri Qurnia Pratiwi Mira Febrina Nesa Agistia ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-29 2022-08-29 128 136 10.22435/jki.v0i0.5950 Pengaruh Variasi Media Pertumbuhan terhadap Aktivitas Peredaman Radikal Bebas DPPH Ekstrak Kapang Endofit Isolat Cb.D1 https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/6029 Endophytic fungi are a source of antioxidant compounds in nature. The low yield of extracts and active compounds produced is one of the limiting factors for using endophytic fungi as a source of natural antioxidant compounds. Modification of growth media is an alternative solution to overcome this problem. This study aimed to determine the effect of media conditions, belonging to carbon and nitrogen sources and different initial pH of fermentation, on the antioxidant through DPPH radical scavenging activity of extract of endophytic fungi Cb.D1 isolated from cinnamon plant leaves. The culture was propagated using Czapek Dox Broth basal liquid medium with agitation speed 120 rpm at room temperature for 14 days. The carbon sources used were glucose, sucrose, and soluble starch. The nitrogen sources were natrium nitrate, ammonium nitrate, and yeast extract. The initial pH conditions used were 5, 7, and 9, and ethyl acetate as the extraction solvent. The results obtained that the variation of nitrogen and carbon sources and also initial pH conditions can increase the yield of extract of endophytic fungi Cb.D1. Glucose, yeast extract, and initial pH at 9 were the best growth media to gain it. The substitution of nitrogen sources and initial pH can increase the DPPH free radical scavenging activity of endophytic fungal extract compared to substitution for carbon sources. The highest activity from the Cb.D1 endophytic fungal extract was obtained from media that contain sucrose and natrium nitrate as a carbon and nitrogen sources and an initial pH of 5. The Variation of growth media of endophytic fungi Cb.D1 affected their extract in DPPH free radical scavenging activity. Ayu Purnamasari Fitri Andriyaningsih Riska Andriani Pamungkas Eris Septiana ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-31 2022-08-31 137 144 10.22435/jki.v0i0.6029 Determination of HPLC Chromatogram Profile of Katuk (Breynia androgyna (L.) Chakrab. & N.P.Balakr) Plants from Ristoja's Results using Chemometric Analysis https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/6040 The katuk plant was known as Sauropus androgynous (L.) Merr, but the name is changed to Breynia androgyna (L.) Chakrab. & N.P. Balakr since the publication of Chakrab's & N.P. Balakr in the 2012 Journal of Plant Taxonomists. The content of chemical compounds and secondary metabolites of katuk leaf are strongly influenced by different habitat or location. Therefore, the Center for Research and Development of Medicinal Plants and Traditional Medicines, National Institute of Health Research and Development (NIHRD) has conducted Research on medicinal plants and herbs (RISTOJA) results on 58 samples of katuk plants originating from 7 provinces and used by 13 ethnic groups in Indonesia. This study aims to obtain plant quality based on the description of the High-Performance Liquid Chromatography (HPLC) chromatogram profile, in order to obtain the suitability of the efficacy of medicinal plants with their benefits for the community in an area. Test using HPLC with a gradient mobile phase, mixture of acetonitrile and methanol for 60 minutes. The results of the chromatogram were analyzed chemometrically by using Principal Component Analysis (PCA) data interpretation. PCA results showed that from HPLC chromatograms at 254 nm and 366 nm, each gave 3 different clusters, namely Clusters A, B and C where each cluster has the same chromatogram profile of katuk plants. Cluster A which was identified at a wavelength of 254 nm was the most used cluster by 7 ethnic groups with a total of 28 Katuk samples. Similarly, the chromatogram at a wavelength of 366 nm with the largest cluster is cluster A which is used by 11 ethnic groups with a total of 45 samples of katuk plants. where each cluster had the same chromatogram profile of katuk Plants. Nanang Yunarto Sukmayati Alegantina Ani Isnawati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-30 2022-08-30 145 154 10.22435/jki.v0i0.6040 Pengaruh Fraksi Daun Asam Jawa (Tamarindus indica L.) terhadap Fungsi Hati dan Ginjal Tikus Diinduksi Parasetamol https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5955 Liver and kidneys play a role in the metabolism and excretion of substances that enter the body, they become targets for toxicity from xenobiotics and other chemicals including drugs. Exogenous antioxidants are needed to overcome and prevent oxidative stress. Fraction of tamarind leaf extract (Tamarindus indica L) has antioxidant activity, it has the potential to protect the body from free radicals. This study aimed to determine the effect of giving tamarind leaf fractions on AST, ALT and creatinine levels in rats (Rattus norvegicus) induced with paracetamol. Experimental animals were divided into 4 groups. Group I was given paracetamol induction (negative control), group II was given the ethyl acetate fraction and induced paracetamol, group III was given the n-hexane fraction and induced paracetamol, and group IV was without treatment (positive control). Statistical analysis using One Way Anova test and LSD (Post Hoc) showed that the ethyl acetate fraction was not significantly different (p-value >0.05) with the positive control group and the n-hexane fraction group, but significantly different from the negative control group (p -value <0.05). The ethyl acetate fraction and the n-hexane fraction of tamarind leaves can suppress the increase in AST, ALT and creatinine levels of rats induced by paracetamol. Sitti Rahimah Akbar Awaluddin Nurzadrina Wahyuddin ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-31 2022-08-31 155 162 10.22435/jki.v0i0.5955 Pengembangan Nutrasetikal Es Krim Daun Kelor (Moringa oleifera L.) https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/6030 Moringa plants ranging from fruit, flowers, leaves, skin, seeds, stems to roots have important benefits. One of the most prominent content of moringa is antioxidants, especially in the leaves which contain high antioxidants. Moringa leaves contain antioxidants in the form of interquinones, flavonoids, tannins, steroids, alkaloids, triterpenoids, and saponins. Moringa leaves also contain vitamin C, calcium, B vitamins, iron, vitamin A, potassium and large amounts of protein that are easily digested and absorbed by the body. The use of moringa plants in Indonesia is currently still limited. One of the efforts to increase the utilization of moringa leaves is through the development of nutraceutical products of Moringa Leaf ice cream. This study aims to obtain a nutraceutical formulation of moringa leaf ice cream for and antioxidant activity. This research is an experimental study by conducting experiments to make Moringa Leaf powder by drying at room temperature and used as an additive in ice cream products and measuring antioxidant activity. This study shows that moringa leaf powder can be formulated into nutraceutical ice cream preparations, the antioxidant activity of moringa leaf powder 50 mg and 5% ice cream is classified as weak, moringa leaf powder 100 mg and 150 mg and 10% and 15% ice cream is classified as moderate and the antioxidant activity is moderate. Moringa leaf powder did not change after being formulated into a nutraceutical preparation of moringa leaf ice cream. Takdir Ul Haq ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-08-30 2022-08-30 163 169 10.22435/jki.v0i0.6030