Jurnal Kefarmasian Indonesia https://ejournal2.litbang.kemkes.go.id/index.php/jki <p>ISSN media elektronik:&nbsp;<a href="http://u.lipi.go.id/1387251248">2354-8770</a></p> <p>ISSN media cetak:&nbsp;<a href="http://u.lipi.go.id/1329660553">2085-675X</a></p> <p>Acredited by Kemenristek/BRIN Accreditation 200/M/KPT/2020 Sinta 2 Valid until Volume 15 Number 1, 2025</p> <p>Jurnal Kefarmasian Indonesia is a scientific journal published by Center for Research and Development of Biomedical and Basic Health Technology, Board of Health Research and Development, Ministry of Health Republic of Indonesia (Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan&nbsp;Kementerian Kesehatan Republik Indonesia). The journal publishes conceptual thinking or ideas pharmacy policy and original research articles in pharmaceutical science such as Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines and Pharmaceutical Care. The journal is published in Bahasa Indonesia and English. Jurnal Kefarmasian Indonesia is a biannual, open access, peer-reviewed and online pharmacy journal. Jurnal Kefarmasian Indonesia aims to serve the updated scientific knowledge for processing manuscript as well as for processing manuscript.</p> <p>Jurnal Kefarmasian Indonesia has been indexed by <a href="https://doaj.org/toc/2354-8770?source=%7B%22query%22%3A%7B%22filtered%22%3A%7B%22filter%22%3A%7B%22bool%22%3A%7B%22must%22%3A%5B%7B%22term%22%3A%7B%22index.issn.exact%22%3A%222085-675X%22%7D%7D%2C%7B%22term%22%3A%7B%22index.issn.exact%22%3A%222354-8770%22%7D%7D%2C%7B%22term%22%3A%7B%22_type%22%3A%22article%22%7D%7D%5D%7D%7D%2C%22query%22%3A%7B%22match_all%22%3A%7B%7D%7D%7D%7D%2C%22from%22%3A0%2C%22size%22%3A100%7D">DOAJ</a>; <a href="http://isjd.pdii.lipi.go.id/index.php/public_no_login/index_direktori">Indonesian Scientific Journal Database</a>, <a href="http://id.portalgaruda.org/?ref=browse&amp;mod=viewjournal&amp;journal=4889">Indonesian Publication Index</a>, <a href="https://www.base-search.net/Record/1497b5f9cf595ef0ff1193d5afab7b2f432efcff10643f42eacaf41a5aa3aa83/">Bielefeld Academic Search Engine</a>, <a href="http://oaji.net/journal-detail.html?number=825">Open Academic Journal Index</a>; <a href="https://scholar.google.co.id/citations?user=gASqT4MAAAAJ&amp;hl=en">Google Scholar</a>; <a title="Sinta" href="http://sinta2.ristekdikti.go.id/journals/detail?id=2785">Sinta</a> Garda Rujukan Digital (<a href="http://garuda.ristekdikti.go.id/journal/view/4889">Garuda</a>). See Google Scholar Profile for Jurnal Kefarmasian Indonesia by clicking <a href="https://scholar.google.co.id/citations?user=gASqT4MAAAAJ&amp;hl=en">here</a>.</p> 16 articles of Jurnal Kefarmasian Indonesia has been cited by Scopus. Click <a href="https://drive.google.com/file/d/1cbuQQ_DqFRVjLEgX09LY91s3rkZfL3lI/view?usp=sharing" target="_blank" rel="noopener">&nbsphere</a> for detail (update January 01, 2021). <p>Total citations: 1362</p> <p>Total documents: 127</p> <p>h-index: 18&nbsp; &nbsp; &nbsp;i10-index: 31&nbsp; &nbsp; &nbsp;Impact Factor: 11,34</p> Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan en-US Jurnal Kefarmasian Indonesia 2085-675X Aktivitas Ramuan Herbal sebagai Antagonis Reseptor H1, Relaksan Otot Polos dan Penghambat Degranulasi Sel Mast sebagai Antiasmatik https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/4676 Asthma is still become a major health problem worldwide, affected all ages from pediatrics to adults. The severity of the disease vary from mild to severe and leads to the risk of death. The uses of medicinal plants as antiasthmatic have often been conducted by the local community. The present study was conducted in vitro and in vivo to determine the activities of herbs containing of sembung leaves (Blumea balsamifera L.), kemukus seeds (Piper cubeba L.), teki rhizome (Cyperus rotundus L.), and patikan kebo herbs (Euphorbia hirta L.) with certain ratio as an antiasthmatic. The in vitro test was carried out on isolated smooth muscle cells of guinea pig. Histamine was used to stimulate the contraction of smooth muscle cells of guinea pig trachea. The in vivo test was carried out using guinea pigs which sensitized with ovalbumin and administered with the herbs formula. The trachea of guinea pigs were prepared for histopathological examination and stained on toluidine blue. The result revealed that the antiasthmatic herbs of 1, 2, and 3 showed activities as H1 receptor antagonists. The antiasthmatic herbs of 1, 2, and 3 were able to relax the smooth muscle of guinea pig’s trachea that was experiencing contraction, but in lower level compared to theophylline. The antiasthmatic herbs formula in this study did not have the activity to inhibit mast cell degranulation. Galuh Ratnawati Kiki Damayanti Agung Endro Nugroho ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-25 2022-02-25 1 10 10.22435/jki.v0i0.4676 Efektivitas Kombinasi Ekstrak Kayu Manis (Cinnamomum burmannii) dan Mikroalga (Haematococcus pluvialis) sebagai Krim Tabir Surya: Formulasi, Uji In Vitro, dan In Vivo https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5085 Indonesia is a tropical country with high intensity of sunlight. Exposure to high ultraviolet rays from sunlight on the skin for a long period of time brings negative impacts such as sunburn, erythema, and skin cancer. Counteracting the negative effects of sun exposure, natural sunscreens that are less toxic such as combination of Cinnamomum burmannii and Haematococcus pluvialis extracts are needed. Cinnamaldehyde as the high active compound in cinnamon extract is able to absorb UV-B rays due to a chromophore group in the form of an aromatic ring conjugated to carbonyl group, along astaxanthin content in the Haematococcus pluvialis which is able to ward off free radicals and has an anti-inflammatory function that the combination will be an effective sunscreen active ingredients. The study aims to develop an oil-in-the-water emulsion-type cream that is added as an active ingredient in a combination of Haematococcus pluvialis and Cinnamomum burmannii extracts to produce a sunscreen cream. The combination extracts was tested in vitro with a UV-Vis spectrophotometer and the SPF value. The cream was physically evaluated including homogeneity, spreadability, adhesion, viscosity, pH, and organoleptic tests as well as in vivo test using mice (Mus muculus). The results indicated that the cream formulas qualified for the physical standards, yet the viscosity value unqualified the standard . The in vitro test showed that the highest SPF value reached SPF 12 for the S2 formula with maximum category. In vivo test showed that the entire formula could protect the skin from exposure to UV-B rays by exoterra lamps. Indarto Indarto Taufik Isnanto Farida Muyassaroh Imelda Putri ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-26 2022-02-26 11 24 10.22435/jki.v0i0.5085 Uji Aktivitas Sitotoksik Ekstrak Polar, Semipolar, dan Non-Polar Daun Sambiloto (Andrographis paniculata) terhadap Sel Kanker Hati (HepG2) https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/4875 Cancer is one of the causes of 6 major deaths in the world besides HIV, malaria, and tuberculosis. The incidence of liver cancer cases in 2018 reached 841 thousand, where there were 782 deaths. Modern medicine such as surgery, radiation, and chemotherapy has various drawbacks, high side effects, therapeutics failure, and high costs. Therefore, WHO recommends herbal medicine as a complementary therapy for various diseases, one of which is cancer. Sambiloto is one of the herbal plants that has been widely used by the people of Indonesia. The potential efficacy of sambiloto as a prospective herbal plant has been widely proven both through in vitro and in vivo studies. This study aims to determine the cytotoxic activity and IC50 value of polar, semipolar, and non-polar fractions of sambiloto leaves on HepG2 cells. Each fraction was tested for its cytotoxic activity against HepG2 cells with a concentration of 500; 250; 125; 62.5; 31.25; and 15,625 µg/mL using the MTT method. The results showed that the IC50 value for the polar, semipolar, and non-polar fractions was 82.585; 53,154; 614,349 µg / mL. Based on these results, the ethyl acetate and ethanol fractions of sambiloto leaves had strong cytotoxic activity against HepG2 cells. Andzar Fikranus Shofa Tunas Alam Nuralih Nuralih ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-28 2022-02-28 25 30 10.22435/jki.v0i0.4875 Uji In Vitro Beberapa Kombinasi Antibiotik Antipseudomonas terhadap Pseudomonas aeruginosa yang Resisten terhadap Karbapenem https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5008 Lower respiratory tract, sepsis, or urinary tract infection caused by the multidrug resistance Pseudomonas aeruginosa is common in the hospital, especially in the ICU wards. The treatment against this bacteria requires combination of antibiotics with different mechanism of actions. In this study, several combinations of antibiotics were evaluated in vitro against carbapenem-resistant P. aeruginosa isolated from the ICU of Cipto Mangunkusumo Hospital. The combination of antibiotics tested were ceftazidime-amikacin, ceftazidime-ciprofloxacin, and ciprofloxacin-amikacin. Checkerboard assay to the combination of antibiotics was conducted to assess the in vitro synergistic activity. A total of 22 P. aeruginosa isolates were collected, 16 of them were resistant to ceftazidime, ciprofloxacin, amikacin, as well as carbapenem. The result revealed that the combination of ceftazidime and amikacin showed promising synergistic activity. Conversely, no synergitic activities were shown by the combination of ceftazidime-ciprofloxacin and ciprofloxacin-amikacin. The combination of ceftazidime-amikacin may has potential effect againsts carbapenem-resistant P. aeruginosa in vitro. Dimas Seto Prasetyo Herna Herna Mursinah Mursinah Fera Ibrahim Budiman Bela ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-28 2022-02-28 31 38 10.22435/jki.v0i0.5008 Pola Pengadaan Obat di 4 Apotek Jaringan Wilayah Bumi Serpong Damai (BSD) Tangerang Selatan https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/4937 Pharmacies are an inseparable part of the drug distribution chain until it reaches the patient. However, patients often hear complaints about the availability of drugs in pharmacies because sometimes there are drug shortage. The aim of this study was to identify the drug procurement pattern in four network pharmacies in the Bumi Serpong Damai (BSD) area in 2019. A retrospective study of four network pharmacies in the Bumi Serpong Peace (BSD) area of South Tangerang was carried out. A total of 8,959 samples were obtained by census from procurement documents of all drugs sold beginning in 2019. (A, B, C, and D pharmacies). The ABC and VEN methods were used in this study. The information gathered includes the name of the drug, the unit, the manufacturer's name, the creditor's name, and the amount and selling price. During 2019, four pharmacies had a total of 2,876 medicinal items of pharmacy A, 1,918 medicinal items of pharmacy B, 1,939 medicinal items of pharmacy C, and 2,226 medicinal items of pharmacy D, with a total drug expenditure of pharmacy A Rp.2,649,438;pharmacy B Rp.683,389,661; pharmacy C Rp. 881,540,329; and pharmacy D Rp. 1,245,520,143. Based on the findings of the study, it is possible to conclude that the four pharmacies have the most drugs in the essential category based on the VEN analysis. However, based on the Pareto ABC analysis, there are still many drugs in four network pharmacies in the BSD Region that fall into the Pareto C category, necessitating further investigation of the procurement. Nurwulan Adi Ismaya Rita Dwi Pratiwi Fenita Purnama Sari Indah Gina Aulia Sumarwati Sumarwati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-25 2022-02-25 39 49 10.22435/jki.v0i0.4937 Formulasi dan Uji Aktivitas Antioksidan Krim Biji dan Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.) sebagai Body Scrub https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/4673 Ethanol extract of guava leaf (Psidium guajava L.) contains flavonoids and tannins that are potentially as an antioxidant that may inhibit the activity of free radicals.The aim of this study is to formulate a body scrub cream from ethanol extract of guava leaf (Psidium guajava L.) and test their antioxidant activity.This study used three variations of concentration of ethanol extract 70% of guava leaf (Psidium guajava L.) i.e 1,5%, 2% and 2,5%.Body scrub creams are formulated into O/W type of creams by using guava seeds as a scrub.Evaluation of preparations included organoleptic examination, homogeneity, pH, cream type, stability test, particle size distribution, dispersion test and antioxidant activity test using DPPH method. The evaluation results showed that the physical properties of cream preparations provided good results and meet the requirements of cream preparations.The results of the antioxidant activity test found that the values of IC50 for each formula was F0 (without extract) 379,58 µg / mL, F1 (1,5%) 150,78 µg/mL, F2 (2%) 137,26 µg/mL and F3 (2,5%) 125,84 µg/mL.It can be concluded that body scrub creams of ethanol extract 70% of guava leaves (Psidium guajava L.) has the potential to be developed as a cosmetic preparation that can inhibit free radicals. Noni Rahayu Putri Diana Agustin Khairatun Nisa ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-25 2022-02-25 50 57 10.22435/jki.v0i0.4673 Pengaruh Variasi Konsentrasi Surfaktan Iselux Ultra Mild pada Formulasi Hydrating Facial Wash Potassium Azeloyl Diglycinate https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/4969 Potassium Azeloyl Diglycinate is an innovative molecule that active as a skin hydrating, brightening agent, and treating skin hyperpigmentation. Facial Wash with foam stabilizing agents called surfactants is a facial cleansing soap that used daily to clean dirt and oil on the face. Iselux ultra mild surfactant as a mild surfactant has a low irritation profile, stable to pH and has a soft and abundant foam. This research is an experimental study. Formulating a good Hydrating Facial Wash Potassium azeloyl diglycinate with the addition of of Iselux ultra mild surfactants in various concentration, according to physical and chemical characteristics as well as a facial wash hydration test. Researchers used various concentration of 28: 30: 32% Iselux Ultra Mild for 3 types of formulas. The test results were analyzed by one way ANOVA. The results of testing the characteristics of physical and chemical properties including organoleptic tests, homogeneity, spreadability, foam height, viscosity, and pH as well as hydration evaluation showed that the facial wash was not change during storage for 12 days using the cycling test method. Formula 3 with the highest surfactant concentration met the best qualification on the parameters compared to Formula 1 and Formula 2. The hydration activity test based on the results of the pre and post test showed that the Facial Wash Potassium azeloyl diglycinate had moisturizing activity on the face. Sholichah Rohmani Sonia Karunia Ningrum Wening Dyah Wardhani Wisnu Kundarto ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-26 2022-02-26 58 68 10.22435/jki.v0i0.4969 Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5071 The prevalence of cancer in Indonesia is increasing and various cancer treatments still have shortcomings, cancer recurrence still occurs. Lymphoscintigraphy is a method for detecting disorders of the lymphatic system, which are closely related to cancer cells. Human serum albumin nanocolloid as a lymphoscintigraphic agent consists of particles measuring <100 nm and this size is a parameter that must be met. Optimization of the synthesis of HSA nano colloids with the Central Composite Design Response Surface Methodology method was carried out to obtain the appropriate particle size, using the variables of pH, reaction temperature and reaction time. The method used can reduce the time and cost required for synthesis optimization. The optimization results show that the developed method has a significant effect. The recommended optimum conditions (prediction) are synthesis at pH 7, reaction temperature of 70oC and reaction time of 24 minutes. The particle size prediction results from the software were verified against the experimental results in the laboratory and based on ANOVA analysis it was found that the response value between prediction and validation was smaller than 5%. The optimum prediction could be used in the HSA nano colloid synthesis process. Wening Lestari Sri Setiyowati Triningsih Triningsih Khoirunnisa Fauziah Asyikin Suharmadi Suharmadi Mujamilah Mujamilah Grace Tjungirai Sulungbudi Sumandi Juliyanto ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-22 2022-02-22 69 78 10.22435/jki.v11i1.5071 Eksplorasi Tumbuhan Obat Indonesia untuk Kebugaran: Analisis Data Riset Tumbuhan Obat dan Jamu Tahun 2012, 2015, dan 2017 https://ejournal2.litbang.kemkes.go.id/index.php/jki/article/view/5209 Compounding plants into health ingredients is a promotive-preventive-based health culture, which was identified in the Research on Medicinal Plants and Herbs (Ristoja). The regeneration of traditional healers who mastered herbal formulation is not going well, documentation must be carried out for better knowledge transfer process. This study documented the traditional use of plants to preserve health and fatigue, using data from Ristoja 2012, 2015 and 2017, obtained from the National Institute of Health Research and Development (Indonesian Ministry of Health), data were analyzed descriptively. The data inventory includes grouping of species-family, plant parts, method, frequency, and duration of use, cultivation/non-cultivation, origin, and method of obtaining plants. The results show that the ingredients to preserve health and relieve fatigue have a large diversification, namely 33 families and 60 species. The most widely used are from families Zingiberaceae and Myrtaceae; species Z. officinale, C. domestica, C. xanthorrhiza, P. guajava, S. aromaticum, and S. Polyantum; parts of plant leaves (71,7%) and roots (38,3%;, originally from yards, forests, and fields/gardens; mostly consumed once/day (76,7%). Plants that have been used as ingredients to preserve health and relieve fatigue have several mechanism of action, such as antioxidant, anti-inflammatory, analgesic, glycemic control, blood pressure control, and others. Lusi Kristiana Astridya Paramita Herti Maryani Pramita Andarwati ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2022-02-28 2022-02-28 79 89 10.22435/jki.v0i0.5209