KONSUMSI SELENIUM UNTUK MENCEGAH PENDERITA TOLERANSI GLUKOSA TERGANGGU MENJADI DIABETES MELLITUS TIPE 2

  • Risqa Novita
Keywords: Selenium; TGT; DM tipe 2

Abstract

Latar Belakang. Penderita Toleransi Glukosa Terganggu (TGT) meningkat setiap tahun. Data Riset Kesehatan Dasar (Riskesdas) tahun 2013 menunjukkan prevalensi penderita TGT di wilayah perkotaan Indonesia sebesar 29,9 persen. Penderita TGT dapat berkembang menjadi Diabetes Mellitus (DM) tipe 2, sehingga pencegahan dari TGT menjadi DM tipe 2 sangat penting. Selenium dapat mencegah DM tipe 2 karena bersifat sebagai antioksidan dan berperan dalam metabolisme glukosa. Tujuan. Untuk mengkaji selenium dalam makanan yang dapat dikonsumsi oleh penderita TGT agar tidak menjadi DM tipe 2. Metode. Tulisan ini merupakan kajian dari literatur-literatur yang ada di Google Scholar, Pubmed dan Elsevier dengan pencarian menggunakan kata kunci Selenium, TGT dan DM tipe 2. Hasil. Berdasarkan hasil dari penelusuran literatur, didapatkan hasil bahwa selenium dalam makanan dapat digunakan untuk penderita TGT jika sesuai dosis yang disarankan. Kesimpulan. Selenium dapat dikonsumsi oleh penderita TGT agar tidak menjadi DM tipe 2 sebagai upaya pencegahan agar penderita TGT tidak menjadi DM tipe 2, sebesar 200 µg per hari selama enam minggu dan Selenium yang baik dikonsumsi berbentuk organik yang berasal dari sayuran hijau, sereal, produk hewani dan kacang-kacangan.

References

World Health Organization. Diabetes. Fact Sheet 312. Diunduh dari :http://www.who.int/mediacentre/factsheets/fs312/en/, tanggal. 2 Juli 2017.

International Diabetes Federation. The IDF Diabetes Atlas. International Diabetes Federation 6th edition. Belgium; 2013.

World Health Organization, Definition, Diagnosis, and Classification of Diabetes Mellitus and Its Complications, Report of A WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva: World Health Organization; 1999.

Manaf A. Prediabetes. Subbagian Endokrin Metabolik, Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Andalas / RSUP Dr M Jamil Padang; 2010.

Fridlyand LE, Philipson LH. Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches. Ann N Y Acad Sci. 2005;1066:136-51.

Lu J, Ji W, Zhao M, Wang M, Yan W, Chen M, Ren S, et al. Protamine Zinc Insulin Combined with Sodium Selenite Improves Glycometabolism in The Diabetic KKAy Mice. Scientific Reports.2016;6(26563):1-12.

Rayman MP, Stranges S. Epidemiology of Selenium and Type 2 Diabetes: Can We Make Sense of It? Free Radic Biol Med. 2013;65:1557-64.

Houstis N, Rosen ED, Lander ES. Reactive Oxygen Species Have A Causal Role in Multiple Forms of Insulin Resistance. Nature. 2006;440:944-8.

Mueller AS, Pallauf J. Compendium of The Antidiabetic Effects of Supranutritional Selenate Doses. in Vivo and in Vitro Investigations with Type II Diabetic db/db Mice. J. Nutr. Biochem. 2006;17(8):548-560.

Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, et al. Selenium Stimulates Pancreatic Beta-Cell Gene Expression and Enhances Islet Function. FEBS Lett. 2008;582(15):2333-7.

Bleys J, Navas-Acien A, Guallar E. Serum Selenium and Diabetes in U.S. Adults. Diabetes Care. 2007;30:829-34.

Steinbrenner H, Sies H. Protection Against Reactive Oxygen Species by Selenoproteins. Biochim Biophys Acta. 2009;1790:1478-85.

Goldstein BJ, Mahadev K, Wu X. Redox Paradox: Insulin Action is Facilitated by Insulin-Stimulated Reactive Oxygen Species with Multiple Potential Signaling Targets. Diabetes. 2005;54:311-21.

Hoffmann PR, Marla JB. The Influence of Selenium on Immune Responses. Mol Nutr Food Res. 2008;52(11): 1273-80.

Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, et al. Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).JAMA. 2009;301:39-51.

Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both Maximal Expression of Selenoproteins and Selenoprotein Deficiency Can Promote Development of Type 2 Diabetes- Like Phenotype in Mice. Antioxid Redox Signal. 2011;14:2327-36.

Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of Long-Term Selenium Supplementation on The Incidence of Type 2 Diabetes: A Randomized Trial. Ann Intern Med. 2007;147:217–23.

Pinto, A, Juniper DT, Sanil M, Morgan L, Clark L, Sies H, et al. Supranutritional Selenium Induces Alterations in Molecular Targets Related to Energy Metabolism in Skeletal Muscle and Visceral Adipose Tissue of Pigs. J. Inorg. Biochem. 2012;114:47-54.

Sedighi O, Atieh M, Shokrzadeh M, Hoorshad S. Association Between Plasma Selenium and Glutathione Peroxidase Levels and Severity of Diabetic Nephropathy in Patients with Type Two Diabetes Mellitus. Nephro Urol Mon. 2014; 6(5):21355-59.

Laclaustra M, Saverio S, Navas-Acien A, Ordovas JM, Guallar E. Serum Selenium and Serum Lipids in US Adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis. 2010;210(2):643-8.

Wang X, Zhang W, Chen H, Liao N, Wang Z, Zhang , et al. High Selenium Impairs Hepatic Insulin Sensitivity Through Opposite Regulation of ROS. Toxicol Lett. 2014;224:16-23.

Ogawa Wong AN, Berry MJ, Seale LA. Review Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients. 2016;8:80.

Seyedali A, Berry MJ. Nonsense-Mediated Decay Factors Are Involved in The Regulation of Selenoprotein Mrna Levels During Selenium Deficiency.RNA. 2014;20:1248-56.

Kurokawa S, Takehashi M,Tanaka H, Mihara H, Kurihara T, Tanaka S, Hill K, Burk R, Esaki N. Mammalian Selenocysteine Lyase is Involved in Selenoprotein Biosynthesis. J. Nutr Sci Vitaminol. 2011;57:298-305.

Tobe R, Mihara H, Kurihara T, Esaki N. Identification of Proteins Interacting With Selenocysteine Lyase. Biosci Biotechnol Biochem. 2009;73:1230-32.

Byrns CN, Pitts MW, Gilman CA, Hashimoto AC, Berry MJ. Mice Lacking Selenoprotein P and Selenocysteine Lyase Exhibit Severe Neurological Dysfunction, Neurodegeneration, and Audiogenic Seizure. Biol Chem. 2014; 289:9662-74.

Hellwege JN, Palmer ND, Ziegler JT, Langefeld CD, Lorenzo C, Norris JM, et al. Genetic Variants in Selenoprotein P Plasma 1 Gene (SEPP1) are Associated with Fasting Insulin and First Phase Insulin Response in Hispanics. Gene. 2014;534(1):33-9.

Zhou J, Kaixun H, Xin GL. Selenium and Diabetes - Evidence from Animal Studies. Free Radic Biol Med. 2013;65:1-20.

Othman FB, Mohamed HJBJ, Sirajudeen KNS, Noh MFBM, Rajab NF. The Influence of Selenium Status on Body Composition, Oxidative DNA Damage and Total Antioxidant Capacity in Newly Diagnosed Type 2 Diabetes Mellitus: A Case-Control Study. J Trace Elem Med Biol. 2017;43:106-112.

Vincetia Marco, Grioni S, Alber D, Consonni D, Malagoli C, Agnoli C, et al. Toenail Selenium and Risk of type 2 diabetes: The ORDET Cohort Study. Journal of Trace Elements in Medicine and Biology. 2015;29:145-150.

Galan-Chilet, Grau-Perez M, De Marco G, Guallar E, Martin-Escudero JC, Dominguez-Lucas A, et al. A Gene-Environment Interaction Analysis of Plasma Selenium with Prevalent and Incident Diabetes: The Hortega Study. Redox Biology. 2017;12:798–805.

Li Zhe, Li X, Ju W, Wu G, Yang X, Fu X, et al. High Serum Selenium Levels are Associated with Impaired Fasting Glucose and Elevated Fasting Serum Glucose in Linyi, China. J Trace Elem Med Biol. 2018;45:64-9.

Strangers S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of Long Term Selenium Supplementation on The Incidence of Type 2 Diabetes: A Randomized Trial. Ann Intern Med. 2007;147:217-23.

Published
2018-12-31
How to Cite
1.
Novita R. KONSUMSI SELENIUM UNTUK MENCEGAH PENDERITA TOLERANSI GLUKOSA TERGANGGU MENJADI DIABETES MELLITUS TIPE 2. mgmi [Internet]. 31Dec.2018 [cited 2Oct.2022];10(1):51-4. Available from: https://ejournal2.litbang.kemkes.go.id/index.php/mgmi/article/view/1053