AUTOIMUNITAS SEBAGAI FAKTOR RISIKO HIPERTIROIDISME PADA WANITA USIA SUBUR DI DAERAH REPLETE GANGGUAN AKIBAT KEKURANGAN IODIUM (GAKI)

  • Agus Wibowo
  • Sri Nuryani Wahyuningrum
  • Ina Kusrini
  • Suryati Kumorowulan
  • Ernani Budi Prihatmi
  • Sudarinah Sudarinah
  • Catur Wijayanti
  • Nafisah Nuraini
  • Nur Asiyatul Janah
  • Ismi Setianingsih
  • Palupi Dyah Ayuni
  • Cicik Harfana
  • Mohamad Samsudin
Keywords: Autoimun, hipertiroid, iodium, hormon tiroid

Abstract

Latar belakang. Hormon tiroid memiliki peran penting dalam tubuh manusia selama hidup. Hormon tiroid berperan dalam perkembangan otak dan pematangan sel dan jaringan, peningkatan konsumsi oksigen oleh sel serta berperan dalam sekresi dan pengendalian produksi hormon lainnya. Sekresi hormon tiroid yang berlebihan akan menimbulkan hipertiroid. Hipertiroid banyak terjadi pada wanita usia subur (WUS) dan risikonya 5-10 kali dibandingkan pria. Hipertiroid dapat terjadi karena asupan iodium yang berlebih dalam jangka panjang atau kejadian autoimun seperti pada penyakit Graves. Hipertiroid banyak terjadi pada daerah replete Gangguan Akibat Kekurangan Iodium (GAKI) seperti wilayah Magelang. Tujuan. Penelitian ini bertujuan mengidentifikasi kejadian autoimun sebagai penyebab hipertiroid di daerah replete GAKI. Metode. Penelitian ini menggunakan metode kasus kontrol dengan jumlah responden kelompok kasus hipertiroid sebanyak 24 orang dan kelompok kontrol sebanyak 41 orang. Penentuan responden antar kelompok dengan tapisan hormon TSH dan fT4. Hasil. Nilai rata-rata hormon tiroid yaitu fT4 dan fT3 serta TSH pada kelompok kasus adalah fT4= 2,52 pg/ml; fT3 =2,96 pg/ml; TSH=0,08 µIU/l. Sedangkan pada kelompok kontrol adalah fT4= 1,6 pg/ml fT3= 2,36 pg/ml; TSH=1,65 µIU/l Autoimun berhubungan dengan kejadian hipertiroid (OR: 18,86; 95%CI). Kesimpulan. Titer TR ab (Tyroid Hormone Reseptor antibody) plasma merupakan faktor risiko tertinggi kejadian hipertiroid pada WUS di daerah replete GAKI.

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Published
2018-12-12
How to Cite
1.
Wibowo A, Wahyuningrum S, Kusrini I, Kumorowulan S, Prihatmi E, Sudarinah S, Wijayanti C, Nuraini N, Janah N, Setianingsih I, Ayuni P, Harfana C, Samsudin M. AUTOIMUNITAS SEBAGAI FAKTOR RISIKO HIPERTIROIDISME PADA WANITA USIA SUBUR DI DAERAH REPLETE GANGGUAN AKIBAT KEKURANGAN IODIUM (GAKI). mgmi [Internet]. 12Dec.2018 [cited 3Jul.2020];9(2):139-48. Available from: https://ejournal2.litbang.kemkes.go.id/index.php/mgmi/article/view/600