Jamu formula could reduce plasma cholesterol patients with mild Hypercholesterolemia

Zuraida Zulkarnain; Agus Triyono; Fajar Novianto

doi:10.22435/hsji.v9i2.808

Zuraida Zulkarnain
Agus Triyono Medicinal Plant and Traditional Medicine Research and Development Office, National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia
Fajar Novianto Medicinal Plant and Traditional Medicine Research and Development Office, National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia

DOI: https://doi.org/10.22435/hsji.v9i2.808

Keywords: hypercholesterolemia, jamu, Saintifikasi Jamu

Abstract

Latar belakang: Pengobatan hiperkolesterolemia sering berlangsung seumur hidup sehingga menyebabkan
penderita meninggalkan obat kimia dan memilih obat herbal. Penelitian ini merupakan uji klinik yang bertujuan
untuk mengetahui khasiat dari formula jamu antikolesterol yang terdiri dari daun jati belanda, daun jati cina,
daun tempuyung, daun teh hijau, rimpang temulawak, rimpang kunyit dan herba meniran dalam menurunkan
kadar kolesterol darah sebagai bagian dari program Saintifikasi Jamu.

Metode: Penelitian ini menggunakan metode kuasi eksperimental dengan desain pre dan post. Jumlah subjek
50 pasien dengan hiperkolesterolemia ringan yang memenuhi kriteria inklusi. Penelitian dilakukan di Rumah
Riset Jamu (RRJ) Hortus Medicus Tawangmangu pada bulan September sampai Desember 2014. Uji statistik
yang digunakan adalah uji t berpasangan dengan bantuan program SPSS 16.

Hasil: Formula jamu antihiperkolesterol yang diminum setiap hari selama 28 hari mampu menurunkan ratarata
kadar kolesterol plasma subjek dari 212.42 mg / dl menjadi 196.6 mg / dl. Uji t test berpasangan didapatkan
hasil p<0,05 yang berarti ada perbedaan rerata kadar kolesterol sebelum dan sesudah pemberian jamu.
Kesimpulan: Formula jamu antihiperkolesterol mampu menurunkan kadar kolesterol plasma pasien
dengan hiperkolesterolemia ringan pada pemberian selama 28 hari. (Health Science Journal of Indonesia
2018;9(2):87-92)

Kata kunci: hiperkosterolemia, jamu, saintifikasi jamu

Abstract

Background: Treatment of hypercholesterolemia often lasts a lifetime, therefore patients leave
chemical drugs and choose herbal medicines. The aim of this clinical study is to evaluate the efficacy of
antihiperkolesterol jamu formula consists of Guazuma ulmifolia leaves, Cassia senna leaves, Sonchus
arvensis leaves, Camellia sinensis leaves, Curcuma xanthorrhiza rhizomes, Curcuma longa rhizomes and
Phyllanthus niruri herbs to lowering cholesterol plasma level as part of Saintifikasi Jamu program.

Methods: This study was a quasi-experimental with pre and post test design. The total subjects were 50
patients with mild hypercholesterolemia who met the inclusion criteria. The research took place at RRJ
‘Hortus Medicus’ Tawangmangu between September to December 2014. The data were analyzed using a
paired t-test with SPSS 16 software.

Results: Results showed jamu anticholesterol formula which is taken every day for 28 days lowered the
mean of cholesterol plasma level of 212.42 mg / dl to 196.6 mg / dl. Paired t test at 95% confidence level
acquired p value <0.05, showed that there is significant differences in the mean cholesterol level subjects
before and after the study.

Conclusion: The administration of jamu antihypercholesterol formula for 28 days could reduce plasma
cholesterol level in subjects with mild hypercholesterolemia. (Health Science Journal of Indonesia
2018;9(2):87-92)

Keywords: hypercholesterolemia, Jamu, Saintifikasi Jamu

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