Hubungan Antara TG/HDL-C dengan Kontrol Glikemik pada Pasien Diabetes di Puskesmas Lebdosari Kota Semarang
Abstract
Abstrak
Prevalensi diabetes melitus meningkat setiap tahun di seluruh dunia. Kontrol glikemik merupakan hal penting dalam pengelolaan pasien Diabetes Mellitus (DM) karena mengurangi risiko komplikasi. Pemeriksaan Glycated Haemoglobin (HbA1C) sebagai gold standard kontrol glikemik dengan target pencapaian HbA1C <7%. Petanda lain faktor risiko terhadap penyakit kardiovaskuler pada pasien DM tipe 2 adalah dislipidemia. Rasio trigliserid terhadap high-density lipoprotein cholesterol (TG/HDL-C) diketahui sebagai indeks atherogenic plasma, yang merupakan faktor risiko utama pada penyakit kardiovaskuler dan sindrom metabolik. Tujuan penelitian ingin mengetahui hubungan antara TG/HDL-C dengan kontrol glikemik pada pasien DM. Penelitian ini merupakan penelitian observasional dengan rancangan penelitian cross sectional yang dilakukan selama 3 bulan (September – November 2020). Subjek penelitian diklasifikasikan berdasarkan kadar HbA1c menjadi 2 grup: 40 pasien DM tipe 2 HbA1c <7% dan 40 pasien DM tipe 2 HbA1c ≥7 %. Analisis statistik menggunakan Mann Whitney dengan signifikansi p ≤ 0,05. Terdapat perbedaan signifikan rasio TG/HDL-C pada kelompok Hb1c < 7% dan kelompok HbA1 c≥ 7% (p=<0,011). Rasio TG/HDL-C pasien DM tipe 2 HbA1c ≥ 7% lebih rendah signifikan dibandingkan DM tipe 2 HbA1c<7 % membuktikan bahwa rasio TG/HDL-C dapat digunakan sebagai alternatif pemeriksaan status pengendalian glukosa darah pada pasien DM tipe 2.
Kata kunci: diabetes melitus, glycated hemoglobin, high density lipoprotein cholesterol, high-performance liquid chromatograph.
Abstract
The prevalence of diabetes is increasing every year all over the world. Glycemic control is important to managing patients with Diabetes Mellitus (DM) because it could decrease complication risk. Glycated Haemoglobin (HbA1C) examination is a gold standard for studying glycemic control with its target of less than 7%. the other risk factor sign of cardiovascular disease in a patient with type 2 DM is dyslipidemia. Trygliserida/high-density lipoprotein cholesterol ratio is known as atherogenic plasma index and is a primary risk factor in cardiovascular disease and metabolic syndrome. An analytic observational study with a cross-sectional approach was conducted in 3 months (September – November 2020). The sample size in this study was 80 patients. They were divided into 2 groups, involving 40 patients with type 2 DM HbA1c <7% and 40 patients with type 2 DM HbA1c ≥7% at Diabetic Clinic, Semarang. TG and HDL-C levels between groups were analyzed using Mann Whitney, p<0.05 were considered significant. There are significant differences in levels of TG/HDL-C ratio between the 2 groups (p =0.001). TG/HDL-C ratio levels were higher in group hbA1c > 7% compared to group HbA1c < 7% can be used as glycemic control in type 2 DM.
Keyword: diabetes melitus, glycated hemoglobin, high density lipoprotein cholesterol, high-performance liquid chromatograph.
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