Faktor Risiko COVID-19 sebagai Dasar Pencegahan dan Pengendalian Infeksi

  • fitriana fitriana Pusat Penelitian dan Pengembangan Sumber Daya dan Pelayanan Kesehatan, Jalan Percetakan Negara No. 29, Jakarta 10560, Indonesia
  • Widianto Pancaharjono Pusat Penelitian dan Pengembangan Sumber Daya dan Pelayanan Kesehatan, Jalan Percetakan Negara No. 29, Jakarta 10560, Indonesia
Keywords: Faktor resiko; COVID-19; Pencegahan infeksi; Pengendalian infeksi, risk factors; COVID-19; infection prevention; infection control

Abstract

Abstrak

Melihat situasi di Indonesia saat ini, dimana kasus konfirmasi COVID-19 dan kematian terus bertambah maka menjadi penting menambah pengetahuan mengenai faktor risiko COVID-19 sebagai upaya pencegahan dan pengendalian infeksi agar tidak semakin bertambah dan meluas. Ada tiga faktor risiko utama yang harus diketahui dapat dinilai yaitu faktor virus itu sendiri, faktor host, dan faktor lingkungan. faktor virus terutama mengetahui bagaimana cara penularan dan pencegahannya. Untuk faktor host apa yang dapat mempengaruhi keparahan penyakit. Dan faktor lingkungan bagaimana yang membuat virus semakin menyebar luas dan hidup lebih lama. Diharapkan dengan bertambahnya pengetahuan dan pemahaman mengenai faktor risiko dari virus SARS CoV-2 maka angka kasus konfirmasi dan kematian dapat dikendalikan. Untuk memutus mata rantai penularan penyakit infeksi hanya melalui tindakkan pencegahan. Hal ini dapat dilakukan jika mengetahui ilmu yang mendasarinya. Untuk itu, tujuan tulisan ini untuk menambah wawasan faktor resiko COVID-19 sebagai dasar untuk pencegahan dan pengendalian infeksi.

 

Kata kunci: Faktor resiko; COVID-19; Pencegahan infeksi; Pengendalian infeksi

 

 

Abstract

Seeing the current situation in Indonesia, where confirmed cases of COVID-19 and deaths continue to increase, it is important to increase knowledge about the risk factors for COVID-19 to prevent and control infection so that it does not increase and spread. We must know three main risk factors to assess: the virus itself, host factors, and environmental factors. First, viral factors, especially knowing how to transmit and prevent it. For what host factors can influence disease severity. And what environmental factors make the virus more widespread and live longer. It is hoped that increased knowledge and understanding of the risk factors of the SARS CoV-2 virus, can control the number of confirmed cases and deaths. Furthermore, to break the chain of transmission of infectious diseases only through preventive measures. Furthermore, can do this if you know the underlying science. The purpose of this paper is to add insight into the risk factors for COVID-19 as a basis for infection prevention and control.

 

Keywords: risk factors; COVID-19; infection prevention; infection control

 

References

Weston S, Frieman MB. COVID-19: Knowns, Unknowns, and Questions. mSphere [Internet]. 2020 e00203-20. doi:10.1128/mSphere.00203-20

Hu Y, Sun J, Dai Z, Deng H, Li X, Huang Q, et al. Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Virol. 2020 Jun;127:104371.doi: 10.1016/j.jcv.2020.104371

Republik Indonesia. Peta Sebaran Covid19.[Internet]. 2021 [diakses pada 22 Desember 2021]. Tersedia pada: https://covid19.go.id/peta-sebaran

Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology, 10nd ed., Philadelphia,PA: Elsevier.2018

Firas A Rabi, Zoubi MS Al, Kasasbeh GA, Salameh DM, Al-Nasser AD. SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. Pathogens. 2020;Mar.doi:10.3390/pathogens9030231

Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of Coronaviruses on Inanimate Surfaces and Their Inactivation With Biocidal Agents. J Hosp Infect. 2020;Mar;104(3):246–51. doi: 10.1016/j.jhin.2020.01.022

Otter JA, Donskey C, Yezli S, Douthwaite S, Goldenberg SD, Weber DJ. Transmission of SARS and MERS Coronaviruses and Influenza Virus in Healthcare Settings: The Possible Role of Dry Surface Contamination. J Hosp Infect. 2016;Mar;92(3):235–50.doi: 10.1016/j.jhin.2015.08.027

Doremalen N van, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared With SARS-CoV-1. N Engl J Med. 2020;Apr 16;382:1564–7. doi: 10.1056/nejmc2004973

Kakodkar P, Kaka N, Baig MN. A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Cureus. 2020;Apr 6;12(4):e7560. doi: 10.7759/cureus.7560

Yan-Rong Guo, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, et al. The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak - An Update on the Status. Mil Med Res. 2020;7(1):11. Published 2020 Mar 13. doi:10.1186/s40779-020-00240-0

Cai J, Sun W, Huang J, Gamber M, Wu J, He G. Indirect Virus Transmission in Cluster of COVID-19 Cases, Wenzhou, China, 2020. Emerging Infectious Diseases. 2020;26(6):1343-1345.doi:10.3201/eid2606.200412.

Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient. JAMA. 2020;323(16):1610-1612.doi:10.1001/jama.2020.3227

Yang R, Gui X, Xiong Y. Patients With Respiratory Symptoms Are at Greater Risk of COVID-19 Transmission. Respir Med. 2020;165:105935. doi:10.1016/j.rmed.2020.105935

Centers for Disease Control and Prevention (CDC). Coronavirus Disease 2019 (COVID-19), How to Protect Yourself & Others [Internet]. 2020. Tersedia pada: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html

World Health Organization (WHO). Coronavirus disease (COVID-19) advice for the public [Internet]. 2020. Tersedia pada: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public

Liu X, Zhou H, Zhou Y, Wu X, Zhao Y, Lu Y, et al. Risk Factors Associated with Disease Severity and Length of Hospital Stay in COVID-19 Patients. J Infect. 2020;81:95–7. doi: 10.1016/j.jinf.2020.04.008

Zhang J, Wang X, Jia X, Li J, Hu K, Chen G, et al. Risk Factors for Disease Severity, Unimprovement, and Mortality in COVID-19 Patients in Wuhan, China. Clin Microbiol Infect. 2020;26(6):767–72.doi: 10.1016/j.cmi.2020.04.012

Zhou Y, Zhang Z, Tian J, Xiong S. Risk Factors Associated with Disease Progression in Cohort of Patients Infected with The 2019 Novel coronavirus. Ann Palliat Med. 2020;9(2):428–36. doi: 10.21037/apm.2020.03.26

Li X, Wang L, Yan S, Yang F, Xiang L, Zhu J, et al. Clinical Characteristics of 25 Death Cases with COVID-19: A Retrospective Review of Medical Records in a Single Medical Center, Wuhan, China. Int J Infect Dis. 2020;94:128–32. doi: 10.1016/j.ijid.2020.03.05

Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, et al. COVID-19 with Different Severities: A Multicenter Study of Clinical Features. Am J Respir Crit Care Med. 2020;201(11):1380–8. doi: 10.1164/rccm.202002-0445oc

Wang R, Pan M, Zhang X, Han M, Fan X, Zhao F, et al. Epidemiological and Clinical Features of 125 Hospitalized Patients with COVID-19 in Fuyang, Anhui, China. Int J Infect Dis. 2020;95:421–8. doi: 10.1016/j.ijid.2020.03.070

Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk Factors for Severity and Mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146(1):110–8. doi: 10.1016/j.jaci.2020.04.006

Zhu Z, Cai T, Fan L, Lou K, Hua X, Huang Z, et al. Clinical Value of Immune Inflammatory Parameters to Assess the Severity of Coronavirus Disease 2019. Int J Infect Dis. 2020;95:332–9.doi: 10.1016/j.ijid.2020.04.041

Wu JT, Leung K, Bushman M, et al. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China [published correction appears in Nat Med. 2020 Jul;26(7):1149-1150]. Nat Med. 2020;26(4):506-510. doi:10.1038/s41591-020-0822-7

Klonoff DC, Umpierrez GE. Letter to the Editor: COVID-19 in patients with diabetes: Risk factors that increase morbidity. Metabolism. 2020;108:154224. doi:10.1016/j.metabol.2020.154224

Liu H, Wang LL, Zhao SJ, Kwak-Kim J, Mor G, Liao AH. Why are pregnant women susceptible to COVID-19? An immunological viewpoint. J Reprod Immunol. 2020;139(February):103122. doi: 10.1016/j.jri.2020.103122

Zheng KI, Gao F, Wang XB, Sun QF, Pan KH, Wang TY, et al. Obesity as a Risk Factor for Greater Severity of COVID-19 in Patients with Metabolic Associated Fatty Liver Disease. Metabolism. 2020;108:154244. doi: 10.1016/j.metabol.2020.154244

Chen R, Liang W, Jiang M, Guan W, Zhan C, Wang T, et al. Risk Factors of Fatal Outcome in Hospitalized Subjects With Coronavirus Disease 2019 From a Nationwide Analysis in China. Chest. 2020;158(1):97–105. doi: 10.1016/j.chest.2020.04.010

Vardavas CI, Nikitara K. COVID-19 and smoking: A systematic review of the evidence. Tob Induc Dis. 2020;18:20. Published 2020 Mar 20. doi:10.18332/tid/119324

Wang B, Li R, Lu Z, Huang Y. Does Comorbidity Increase the Risk of Patients with COVID-19: Evidence from Meta-Analysis. Aging (Albany NY). 2020;12(7):6049–57. doi: 10.18632/aging.103000

Gracia-Ramos AE. Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection? Arch Med Res. 2020;51(4):345–6. doi: 10.1016/j.arcmed.2020.03.011

Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020;323(14):1406-1407. doi:10.1001/jama.2020.2565

Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records [published correction appears in Lancet. 2020 Mar 28;395(10229):1038] [published correction appears in Lancet. 2020 Mar 28;395(10229):1038]. Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3

Liu W, Wang Q, Zhang Q, Chen L, et al. Coronavirus Disease 2019 (COVID-19) During Pregnancy: a Case Series. Preprints 2020, 2020020373

Li T, Zhang Y, Gong C, Wang J, Liu B, Shi L, et al. Prevalence of Malnutrition and Analysis of Related Factors in Elderly Patients with COVID-19 in Wuhan, China. Eur J Clin Nutr. 2020;74(6):871–5. doi: 10.1038/s41430-020-0642-3

Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and Covid-19 Infections and Deaths. Nutrients. 2020;12(4):1–19. doi: 10.3390/nu12040988

Amin Gasmi, Noor S, Tippairote T, Dadar M, Menzel A, Bjørklund G. Individual Risk Management Strategy and Potential Therapeutic Options for the COVID-19 Pandemic. Clin Immuno. 2020;Jun;215:10.doi: 10.1016/j.clim.2020.108409

Xu K, Chen Y, Yuan J, Yi P, Ding C, Wu W, et al. Factors Associated with Prolonged Viral RNA Shedding in Patients with COVID-19. Clin Infect Dis. 2020;2019(Xx):1–8. doi: 10.1093/cid/ciaa351

Du RH, Liang LR, Yang CQ, Wang W, Cao TZ, Li M, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARSCoV- 2: A prospective cohort study. Eur Respir J. 2020;55(5). doi: 10.1183/13993003.00524-2020

Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, et al. Neutrophil-to-Lymphocyte Ratio As An Independent Risk Factor for Mortality in Hospitalized Patients with COVID-19. J Infect. 2020;81:6–12. doi: 10.1016/j.jinf.2020.04.002

Yao Q, Wang P, Wang X, Qie G, Meng M, Tong X, et al. A Retrospective Study of Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Hospitalized Adult Patients. Polish Arch Intern Med. 2020;130(5):390–9. doi: 10.20452/pamw.15312

Gao L, Jiang D, Wen XS, Cheng XC, Sun M, He B, et al. Prognostic Value of NT-proBNP in Patients With Severe COVID-19. Respir Res. 2020;21(1):1–7. doi: 10.1186/s12931-020-01352-w

Khunti K, Singh AK, Pareek M, Hanif W. Is Ethnicity Linked to Incidence or Outcomes of covid-19?. BMJ. Published 2020 Apr 20. doi:10.1136/bmj.m1548

Fan C, Cai T, Gai Z, Wu Y. The Relationship Between the Migrant Population’s Migration Network and the Risk of COVID-19 Transmission in China-Empirical Analysis and Prediction in Prefecture-Level Cities. Int J Environ Res Public Health. 2020;17(8):2630. Published 2020 Apr 11. doi:10.3390/ijerph17082630

Lima NNR, Souza RI de, Feitosa PWG, Moreira JL de S, Silva CGL da, Neto MLR. People Experiencing Homelessness: Their Potential Exposure to COVID-19. Psychiatry Res.2020;288:112945.doi:10.1016/j.psychres.2020.112945

Zhu Y, Xie J, Huang F, Cao L. Association Between Short-Term Exposure to Air Pollution and COVID-19 Infection: Evidence From China. Sci Total Environ. 2020;727:138704. doi:10.1016/j.scitotenv.2020.138704

Shi J, Wen Z, Zhong G, Yang H, Wang C, Huang B, et al. Susceptibility of Ferrets, Cats, Dogs, and Other Domesticated Animals to SARS-Coronavirus 2. Science. 2020;368(6494):1016–20. doi: 10.1126/science.abb7015

Oksanen A, Kaakinen M, Latikka R, Savolainen I, Savela N, Koivula A. Regulation and Trust: 3-Month Follow-up Study on COVID-19 Mortality in 25 European Countries. JMIR Public Health Surveill. 2020;6(2):e19218. Published 2020 Apr 24. doi:10.2196/19218

Qi H, Xiao S, Shi R, Ward MP, Chen Y, Tu W, et al. COVID-19 Transmission in Mainland China Is Associated With Temperature and Humidity: A Time-Series Analysis. Sci Total Environ. 2020;728:138778. doi:10.1016/j.scitotenv.2020.138778

Liu J, Zhou J, Yao J, Zhang X, Li L, Xu X, et al. Impact of Meteorological Factors on the COVID-19 Transmission: A Multi-City Study in China. Sci Total Environ. 2020;726:138513. doi:10.1016/j.scitotenv.2020.138513

Published
2021-08-31
How to Cite
fitriana, fitriana, & Pancaharjono, W. (2021). Faktor Risiko COVID-19 sebagai Dasar Pencegahan dan Pengendalian Infeksi. Jurnal Penelitian Dan Pengembangan Pelayanan Kesehatan, 5(2), 38-45. https://doi.org/10.22435/jpppk.v5i2.5738
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Articles