CORRELATION BETWEEN URIC ACID LEVEL WITH BODY MASS INDEX AND HEMATOLOGY PARAMETERS AMONG HYPERURICEMIA PATIENTS
Keywords:
hematology parameters, body mass index, uric acid
Abstract
Hyperuricemia has became the public health issue worldwide. Hematology parameters abnormality is considered to be one of the factors relating the disease such as hyperuricemia. Current study suggest that body mass index (BMI) related to uric acid (UA) levels. The aim of the study was to examine the association between uric acid levels and hematological parameters and BMI among hyperuricemia patients. This was cross sectional study with 50 hyperuricemia patients in Hortus Medicus clinic. Results demonstrate that of the participants, 54% were women but the mean of UA levels was higher in the men (8,41 + 0,80 mg/dL) than in women (7,38 + 0,97 mg/dL). In BMI classified, the mean BMI for men was normoweight, and the women was overweight. The mean of hematology parameters in both of sex were normal range. No significant association were testified between uric acid levels and hemoglobin, hematocrit, erythrocyte, trombocyt, leukocyte and BMI. This study indicate that uric acid has no apparent association with hematology parameters and BMI
References
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2. Song, P. et al. Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China. Sci. Rep. 1–9 (2018). doi:10.1038/s41598-018-22570-9
3. Zeng, C. et al. Higher blood hematocrit predicts hyperuricemia : a prospective study of 62897 person-years of follow-up. Sci. Rep. 1–11 (2015). doi:10.1038/srep13765
4. Badan Litbang Kesehatan, K. K. R. Riset Kesehatan Dasar. (2013).
5. Woyesa, S. B., Hirigo, A. T. & Wube, T. B. Hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients at Hawassa university comprehensive specialized hospital , South West Ethiopia. BMC Endocr. Disord. 1–8 (2017). doi:10.1186/s12902-017-0226-y
6. Foster, C., Smith, L. & Alemzadeh, R. Excess serum uric acid is associated with metabolic syndrome in obese adolescent patients. J. Diabetes Metab. Disord. 535–543 (2020).
7. Ni, W. et al. Association of Serum Uric Acid with Metabolic Syndrome and Its Components : A Cross-Sectional Study in Chinese Coastal Population. Metab. Syndr. Relat. Disord. 18, 103–109 (2020).
8. Yadav, B. K., Chhetri, G. B., Poudel, B., Sigdel, M. & Gyawali, P. Serum Uric Acid Level in Obese and Non-obese Individuals. J. Nepal Assoc. Med. Lab. Sci. 10, (2009).
9. Bano, S., Joshi, A. R. & Vaidya, S. M. Correlation between serum uric acid level with obesity indices and blood pressure in young males. Natl. J. Physiol. Pharm. Pharmacol. 9, 1103–1106 (2019).
10. Kaur, P., Saxena, N. & Zhu, Z. Effect of Asian BMI on risk of chronic disease progression : A Singapore perspective. in Proceedings of Singapore Healtcare (2018). doi:10.1177/2010105818779400
11. Ji-rong, Y., Chang-quan, H. & Bi-rong, D. Association of serum uric acid with body mass index among long-lived Chinese. Exp. Gerontol. 47, 595–600 (2012).
12. Akinbami, A. A. et al. Hematological profile of normal pregnant women in Lagos , Nigeria. Int. J. Womens. Health 227–232 (2013).
13. Chu, M. et al. Association between lifestyle and hematological parameters : A study of Chinese male steelworkers. J Clin Lab Anal 1–9 (2019). doi:10.1002/jcla.22946
14. Stelmach, M. J., Szczerbinski, L., Wasilewska, N., Protas, P. & Wasilewska, A. Hematological Parameters in Adolescents with Hyperuricemia. Indian Pediatr. 51, 1003–1005 (2014).
15. Su, P., Hong, L., Zhao, Y., Sun, H. & Li, L. The Association Between Hyperuricemia and Hematological Indicators in a Chinese Adult Population. Medicine (Baltimore). 95, 1–6 (2016).
16. Weisell, R. C. Body Mass Index as an Indicator of Obesity. Asia Pacific J Clin Nutr 11, (2002).
17. Islamagic, E., Lisovac, A., Focak, M. & Suljevic, D. Comorbidity and Gout : Association between Hyperuricemia and Blood Parameters as a Predictor of Gout. J. IMAB 26, 3092–3097 (2020).
18. Shirasawa, T., Ochiai, H., Yoshimoto, T., Nagahama, S. & Watanabe, A. Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan. BMC Endocr. Disord. 1–8 (2020).
19. Kumalasari, T. S., Saryono & Purnawan, I. Hubungan Indeks Massa Tubuh dengan Kadar Asam Urat Darah pada Penduduk Desa Banjaranyar Kecamatan Sokaraja Kabupaten Banyumas. J. Keperawatan Soedirman (The Soedirman J. Nursing) 4, 119–124 (2009).
20. Eun, Y. et al. Association between anemia and hyperuricemia : results from the Korean National Health and Nutrition Examination Survey. Sci. Rep. 1–8 (2019). doi:10.1038/s41598-019-55514-y
21. Mcadams-demarco, M. A., Maynard, J. W., Coresh, J. & Baer, A. N. Anemia and the onset of gout in a population- based cohort of adults : Atherosclerosis Risk in Communities study. Arthritis Res. Ther. 14, R193 (2012).
22. Zhang, C. et al. No associations exists between red blood cell distribution width and serum uric acid in both sexes. Medicine (Baltimore). (2018).
23. Verdoia, M. et al. Impact of diabetes on uric acid and its relationship with the extent of coronary artery disease and platelet aggregation: A single-centre cohort study. Metabolism 63, 640–646 (2014).
24. Liu, J. et al. White blood cell count and the incidence of hyperuricemia : insights from a community-based study. Front. Med. (2018).
25. Shen, L. et al. The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia. ResearchGate 1–25 (2020).
26. Merriman, T. & Dalbeth, N. The genetic basis of hyperuricaemia gout. Jt. Bone Spine 35–40 (2011). doi:10.1016/j.jbspin.2010.02.027
27. Li, S. et al. The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. Plos Genet. 3, (2007).
28. Jamnik, J. et al. Fructose intake and risk of gout and hyperuricemia : a systematic review and meta-analysis of prospective cohort studies. BMJ Open (2016). doi:10.1136/bmjopen-2016-013191
29. Li, R., Yu, K. & Li, C. Dietary factors and risk of gout and hyperuricemia : a meta-analysis and systematic review. Asia Pacific J Clin Nutr 27, 1344–1356 (2018).
30. Gunawardena, D., Jayaweera, S., Madhubhashini, G., Lokumarakkala, D. D. & Senanayake, S. J. Reliability of Parameters of Complete Blood Count With Different Storage Conditions. J. Clin. Lab. Anal. (2017). doi:10.1002/jcla.22042
31. Nilsson, G., Hedberg, P. & Öhrvik, J. White Blood Cell Count in Elderly Is Clinically Useful in Predicting Long-Term Survival. J. Aging Res. (2014).
32. Nilsson, G., Hedberg, P., Jonason, T., Lönnberg, I. & Tenerz, Å. White Blood Cell Counts Associate More Strongly to the Metabolic Syndrome in 75-Year-Old Women Than in Men: A Population Based Study. Metab. Syndr. Relat. Disord. 5, 359–364 (2007).
33. Ruggiero, C. et al. White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging. J. Am. Coll. Cardiol. 49, (2007).
Published
2021-11-30
How to Cite
1.
fitriani ulfa, zulkarnain zuraida, wijayanti enggar. CORRELATION BETWEEN URIC ACID LEVEL WITH BODY MASS INDEX AND HEMATOLOGY PARAMETERS AMONG HYPERURICEMIA PATIENTS. sel [Internet]. 30Nov.2021 [cited 3Jul.2024];8(2):66 -74. Available from: http://ejournal2.litbang.kemkes.go.id/index.php/sel/article/view/4382
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